A systematic review and meta-analysis of pregnancy-associated breast cancer incidence rate

被引：0
作者：
Mohammad Akhlaqi [1 ]
Amirali Ghofrani [1 ]
Nazila Najdi [2 ]
Mohammadhosein Ranjkesh [3 ]
Amir Almasi-Hashiani [4 ]
机构：
[1] Student Research Committee, Arak University of Medical Sciences, Arak
[2] Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak
[3] Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran
[4] Department of Epidemiology, School of Health, Arak University of Medical Sciences, Golestan St., Arak
[5] Traditional and Complementary Medicine Research Center, School of Medicine, Arak University of Medical Sciences, Arak
来源：
BMC Cancer | / 25卷 / 1期
关键词：
Breast neoplasm; Gestational breast cancer; Meta-analysis; Pregnancy associated breast cancer;
D O I：
10.1186/s12885-025-14091-2
中图分类号：
学科分类号：
摘要：
Background: Pregnancy-Associated Breast Cancer (PABC) is a special type of breast cancer that either occurs during pregnancy or one year postpartum. The aim of this systematic review and meta-analysis is to investigate the global incidence of PABC. Methods: In this meta-analysis, to find related studies, three international databases including PubMed (Medline), Scopus and Web of Science (Clarivate analytics) were explored. An additional search was also carried out using Google Scholar in December 2023 looking for any new relevant article, and the list of references for all new supposedly relevant papers were manually searched for and investigated as well. The required data were extracted from retrieved studies and the quality of the studies was evaluated using the Newcastle–Ottawa scale checklist. Heterogeneity among studies was assessed by I-square statistic and chi-square test and due to presence of a significant heterogeneity among studies, a random-effects model was used to pool the data. Results: Twenty-two studies were included in this meta-analysis. Among 51,944,490 number of female individuals included in the study, a total number of 7,267 cases of PABC were identified. Based on these results, the global incidence of PABC was estimated 19.2 cases per 100,000 pregnancies (95%CI: 16.1–22.2, I-square = 98.9%). The results of cumulative analysis showed that the incidence rate of PABC has risen over decades, as it increased from 13.3 cases (in 1969) to 19.2 cases (in 2022) per 100,000 pregnancies. The lowest incidence rate belonged to the American continent with 14.4 (95%CI: 9.8–19) cases per 100,000 pregnancies. Conclusions: The results obtained from this study demonstrates that the global incidence of PABC amounts to 19.2 cases per 100,000 pregnancies and it has been increasing slowly during the last few decades as time went by. The incidence rate in developing countries seem to be higher than in the developed countries. However, more studies are required in order to reach a better conclusion on this issue. © The Author(s) 2025.
引用
收藏
相关论文
共 48 条
  • [1] Jin Y.C., Du J.X., Fu S.M., Chen Q., Qiu Y.R., Pei A., Yao Y.J., Zhu W., Wu K.J., A retrospective clinical study of patients with pregnancy-associated breast cancer among multiple centers in China (CSBrS-008), Chin Med J, 134, 18, pp. 2186-2195, (2021)
  • [2] Pyle C., Hill M., Sharafi S., Forton C., Sohaey R., Pregnancy-associated breast cancer: why breast imaging during pregnancy and lactation matters, J Breast Imaging, 5, 6, pp. 732-743, (2023)
  • [3] Lundberg F.E., Stensheim H., Ullenhag G.J., Sahlgren H.M., Lindemann K., Fredriksson I., Johansson A.L.V., Risk factors for the increasing incidence of pregnancy-associated cancer in Sweden - a population-based study, Acta Obstet Gynecol Scand, 103, 4, pp. 669-683, (2024)
  • [4] Lee G.E., Mayer E.L., Partridge A., Prognosis of pregnancy-associated breast cancer, Breast Cancer Res Treat, 163, 3, pp. 417-421, (2017)
  • [5] Anders C.K., Johnson R., Litton J., Phillips M., Bleyer A., Breast cancer before age 40 years, Semin Oncol, 36, 3, pp. 237-249, (2009)
  • [6] Vinatier E., Merlot B., Poncelet E., Collinet P., Vinatier D., Breast cancer during pregnancy, Eur J Obstet Gynecol Reprod Biol, 147, 1, pp. 9-14, (2009)
  • [7] Polivka J., Altun I., Golubnitschaja O., Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine, EPMA J, 9, 1, pp. 1-13, (2018)
  • [8] Ruiz R., Herrero C., Strasser-Weippl K., Touya D., St Louis J., Bukowski A., Goss P.E., Epidemiology and pathophysiology of pregnancy-associated breast cancer: a review, Breast, 35, pp. 136-141, (2017)
  • [9] Kakoulidis I., Skagias L., Politi E., Pregnancy associated breast cancer (PABC): aspects in diagnosis, Breast Dis, 35, 3, pp. 157-166, (2015)
  • [10] Wang B., Yang Y., Jiang Z., Zhao J., Mao Y., Liu J., Zhang J., Clinicopathological characteristics, diagnosis, and prognosis of pregnancy-associated breast cancer, Thorac Cancer, 10, 5, pp. 1060-1068, (2019)
12345