Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

被引：0

作者：

Jaerke, Lea ^{[1
]}

Weber-Stiehl, Saskia ^{[1
]}

Shima, Kensuke ^{[2
]}

Moors, Karlis Arturs ^{[3
]}

Genth, Jerome ^{[3
]}

Schuran, Fenja Amrei ^{[1
]}

Best, Lena ^{[3
]}

Tschurtschenthaler, Markus ^{[4
,5
,6
,7
,8
]}

Flemer, Burkhardt ^{[1
]}

Lueschen, Silke ^{[9
]}

Roecken, Christoph ^{[9
]}

Tholey, Andreas ^{[3
]}

Kaleta, Christoph ^{[3
]}

Rupp, Jan ^{[2
,10
,11
]}

Rosenstiel, Philip ^{[1
]}

Sommer, Felix ^{[1
]}

机构：

[1] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

[2] Univ Lubeck, Inst Med Microbiol, Lubeck, Germany

[3] Univ Kiel, Inst Expt Med, Kiel, Germany

[4] Tech Univ Munich, Translat Canc Res, Munich, Germany

[5] Tech Univ Munich, Inst Expt Canc Therapy, Sch Med & Hlth, Klinikum Rechts Isar, Munich, Germany

[6] Tech Univ Munich, Ctr Translat Canc Res TranslaTUM, Sch Med & Hlth, Klinikum Rechts Isar, Munich, Germany

[7] German Canc Res Ctr, Div Translat Canc Res, Heidelberg, Germany

[8] German Canc Consortium DKTK, Heidelberg, Germany

[9] Univ Hosp Schleswig Holstein, Dept Pathol, Campus Kiel, Kiel, Germany

[10] Univ Hosp Schleswig Holstein, Infect Dis Clin, Campus Lubeck, Lubeck, Germany

[11] German Ctr Infect Res DZ, Partner Site Hamburg Lubeck Borstel Riems, Lubeck, Germany

来源：

CANCER COMMUNICATIONS | 2025年

关键词：

D O I：

10.1002/cac2.70022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页数：6

共 10 条

[1] The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore
Baines, Christopher P.
Gutierrez-Aguilar, Manuel
[J]. CELL CALCIUM, 2018, 73 : 121 - 130
[2] HKDC1 C-terminal based peptides inhibit extranodal natural killer/T-cell lymphoma by modulation of mitochondrial function and EBV suppression
Chen, Qi
Feng, Jia
Wu, Jinhu
Yu, Zhendong
Zhang, Wei
Chen, Yonggang
Yao, Paul
Zhang, Hongyu
[J]. LEUKEMIA, 2020, 34 (10) : 2736 - 2748
[3] A functional methylome map of ulcerative colitis
Haesler, Robert
Feng, Zhe
Baeckdahl, Liselotte
Spehlmann, Martina E.
Franke, Andre
Teschendorff, Andrew
Rakyan, Vardhman K.
Down, Thomas A.
Wilson, Gareth A.
Feber, Andrew
Beck, Stephan
Schreiber, Stefan
Rosenstiel, Philip
[J]. GENOME RESEARCH, 2012, 22 (11) : 2130 - 2137
[4] Hallmarks of Cancer: The Next Generation
Hanahan, Douglas
Weinberg, Robert A.
[J]. CELL, 2011, 144 (05) : 646 - 674
[5] Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association Studies
Hayes, M. Geoffrey
Urbanek, Margrit
Hivert, Marie-France
Armstrong, Loren L.
Morrison, Jean
Guo, Cong
Lowe, Lynn P.
Scheftner, Douglas A.
Pluzhnikov, Anna
Levine, David M.
McHugh, Caitlin P.
Ackerman, Christine M.
Bouchard, Luigi
Brisson, Diane
Layden, Brian T.
Mirel, Daniel
Doheny, Kimberly F.
Leya, Marysa V.
Lown-Hecht, Rachel N.
Dyer, Alan R.
Metzger, Boyd E.
Reddy, Timothy E.
Cox, Nancy J.
Lowe, William L., Jr.
[J]. DIABETES, 2013, 62 (09) : 3282 - 3291
[6] The hexokinase "HKDC1" interaction with the mitochondria is essential for liver cancer progression
Khan, Md Wasim
Terry, Alexander R.
Priyadarshini, Medha
Ilievski, Vladimir
Farooq, Zeenat
Guzman, Grace
Cordoba-Chacon, Jose
Ben-Sahra, Issam
Wicksteed, Barton
Layden, Brian T.
[J]. CELL DEATH & DISEASE, 2022, 13 (07)
[7] HKDC1 functions as a glucose sensor and promotes metabolic adaptation and cancer growth via interaction with PHB2
Liu, Panpan
Luo, Yao
Wu, Hongyu
Han, Yi
Wang, Shoujie
Liu, Rui
Wen, Shijun
Huang, Peng
[J]. CELL DEATH AND DIFFERENTIATION, 2024, 31 (12) : 1595 - 1610
[8] A DOMINANT MUTATION THAT PREDISPOSES TO MULTIPLE INTESTINAL NEOPLASIA IN THE MOUSE
MOSER, AR
PITOT, HC
DOVE, WF
[J]. SCIENCE, 1990, 247 (4940) : 322 - 324
[9] HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway
Wang, Xinyu
Shi, Bowen
Zhao, Yue
Lu, Qijue
Fei, Xiang
Lu, Chaojing
Li, Chunguang
Chen, Hezhong
[J]. CANCER CELL INTERNATIONAL, 2020, 20 (01)
[10] HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression
Zhang, Yi
Wang, Mingjie
Ye, Ling
Shen, Shengqi
Zhang, Yuxi
Qian, Xiaoyu
Zhang, Tong
Yuan, Mengqiu
Ye, Zijian
Cai, Jin
Meng, Xiang
Qiu, Shiqiao
Liu, Shengzhi
Liu, Rui
Jia, Weidong
Yang, Xianzhu
Zhang, Huafeng
Zhong, Xiuying
Gao, Ping
[J]. NATURE COMMUNICATIONS, 2024, 15 (01)

← 1 →