Hypothalamic corticotropin-releasing hormone neurons modulate sevoflurane anesthesia and the post-anesthesia stress responses

被引:2
作者
Jiang, Shan [1 ,2 ,3 ]
Chen, Lu [1 ,2 ,3 ]
Qu, Wei-Min [1 ,2 ,3 ]
Huang, Zhi-Li [1 ,2 ,3 ]
Chen, Chang-Rui [1 ,2 ,3 ]
机构
[1] Fudan Univ, Inst Brain Sci, Sch Basic Med Sci, Dept Pharmacol, Shanghai, Peoples R China
[2] Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China
[3] Fudan Univ, Inst Brain Sci, MOE Frontiers Ctr Brain Sci, Shanghai, Peoples R China
基金
美国国家科学基金会;
关键词
general anesthesia; stress response; paraventricular nucleus of the hypothalamus; corticotropin-releasing hormone; sevoflurane; NUCLEUS; ANXIETY; NEUROBIOLOGY; STIMULATION; DESFLURANE; ACTIVATION; FOREBRAIN; EMERGENCE; AREA; AXIS;
D O I
10.7554/eLife.90191
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
General anesthesia (GA) is an indispensable procedure necessary for safely and compassionately administering a significant number of surgical procedures and invasive diagnostic tests. However, the undesired stress response associated with GA causes delayed recovery and even increased morbidity in the clinic. Here, a core hypothalamic ensemble, corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus (PVHCRH neurons), is discovered to play a role in regulating sevoflurane GA. Chemogenetic activation of these neurons delay the induction of and accelerated emergence from sevoflurane GA, whereas chemogenetic inhibition of PVHCRH neurons accelerates induction and delays awakening. Moreover, optogenetic stimulation of PVHCRH neurons induce rapid cortical activation during both the steady and deep sevoflurane GA state with burst-suppression oscillations. Interestingly, chemogenetic inhibition of PVHCRH neurons relieve the sevoflurane GA-elicited stress response (e.g., excessive self-grooming and elevated corticosterone level). These findings identify PVHCRH neurons modulate states of anesthesia in sevoflurane GA, being a part of anesthesia regulatory network of sevoflurane.
引用
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页数:28
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