Advancing Cancer Vaccines with Radionuclide Imaging

被引：0

作者：

Cheng, Sixuan ^{[1
]}

Long, Xingru ^{[1
]}

Zhang, Yongxue ^{[2
]}

Lan, Xiaoli ^{[3
]}

Jiang, Dawei ^{[3
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Nucl Med, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

[2] Hubei Prov Key Lab Mol Imaging, Wuhan 430022, Peoples R China

[3] Minist Educ, Key Lab Biol Targeted Therapy, Wuhan 430022, Peoples R China

来源：

SMALL | 2025年 / 21卷 / 02期

基金：

中国国家自然科学基金;

关键词：

cancer vaccines; nuclear medicine; PET; radionuclide imaging; SPECT; IN-VIVO; DENDRITIC CELLS; IMMUNE-RESPONSE; F-18-FLT PET; LUNG-CANCER; OPEN-LABEL; T-CELLS; FDG-PET; IMMUNOTHERAPY; ANTIGEN;

D O I：

10.1002/smll.202406950

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cancer vaccines are emerged as a beacon of hope in the fight against cancer. However, the lack of effective methods to directly observe their in vivo behavior and monitor therapeutic responses hinders their translation into clinical settings. Radionuclide imaging allows for non-invasive and real-time visualization of vaccine biodistribution and immunological response, offering valuable insights into the effectiveness of cancer vaccines and aiding in patient stratification. In this review, the latest advances and potential applications of radionuclide imaging in cancer vaccines are discussed, with a specific focus on strategies for visualizing the spatiotemporal distribution of vaccines in vivo and monitoring treatment efficacy. The challenges and considerations for implementing these techniques in clinical practice are also highlighted, aiming to inform and guide future research in this field.

引用

页数：14

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