One-Pot, Three-Component Borrowing Hydrogen/Cyclization Synthesis of Benzimidazoles

被引：0

作者：

Xu, Feng ^{[1
]}

Yu, Hui ^{[2
]}

Zhang, Lilong ^{[3
]}

机构：

[1] Guiyang Univ, Sch Mat Sci, Jianlongdong 103 Rd, Guiyang 550005, Guizhou, Peoples R China

[2] Guizhou Univ Tradit Chinese Med, Shizhen Coll, Dept Pharm, Guiyang 550200, Guizhou, Peoples R China

[3] Guizhou Univ, Natl Key Lab Green Pesticide, State Local Joint Lab Comprehens Utilizat Biomass, Key Lab Green Pesticide & Agr Bioengn,Minist Educ,, Guiyang 550025, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 28卷 / 14期

关键词：

Multicomponent reaction; Hydrogen borrowing coupling; Benzimidazole; Organic nitrogen hydroxyl; EFFICIENT CATALYST; AROMATIC DIAMINES; ALCOHOLS; SOLVENT; CONDENSATION; CYCLIZATION; OXIDATION; COMPLEXES;

D O I：

10.1002/ejoc.202401441

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multicomponent reactions are an efficient toolbox of access to complex compounds, but the development of multicomponent reactions involved in benzimidazole synthesis is still limited. Herein, a one-pot, three-component reaction involving nitrobenzene, benzyl alcohol, and sulfonyl azide was developed for the synthesis of benzimidazoles employing Co-complexes (Salen Co-NHPI) as catalyst, which by self-assembly from salen ligands, organic nitrogen hydroxyl compounds, and CoCl2. Compared with previously reported three-component methods for the construction of benzimidazoles, this method involves a novel hydrogen borrowing/cyclization and can provide a variety of benzimidazole in moderate to excellent yields.

引用

页数：5

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