Impact of the COVID-19 pandemic on epidemiological and clinical characteristics of Mycoplasma pneumoniae pneumonia in children: a multicenter study from Hubei, China

被引:1
作者
Du, Hui [1 ]
Li, Jun [2 ]
Li, Xilin [3 ]
Zhao, Junhua [4 ]
Lu, Wei [5 ]
Zhang, Qiong [6 ]
Liu, Wenchun [7 ]
Luo, Xinbing [8 ]
Lu, Qiao [9 ]
Hu, Sanhong [10 ]
Ma, Jilong [11 ]
He, Renzhong [12 ]
Sha, Bangwu [13 ]
Zhang, Lihua [14 ]
Wu, Jinhui [15 ]
Yang, Junjie [16 ]
Li, Hongli [17 ]
Chen, Hebin [1 ]
Li, Ying [1 ]
Li, Yang [1 ]
Lin, Yaxin [1 ]
Liu, Yuehu [1 ]
Wu, Yabin [18 ]
Liu, Yang [19 ]
Li, Jianmu [20 ]
Lu, Xiaoxia [1 ]
机构
[1] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Dept Resp Med, Wuhan, Peoples R China
[2] Maternal & Child Hlth Hosp Huangshi, Dept Pediat, Huangshi, Peoples R China
[3] Peoples Hosp Xishui, Dept Pediat, Huanggang, Peoples R China
[4] Xiantao Maternal & Child Hlth Hosp, Dept Pediat, Xiantao, Peoples R China
[5] Yichang Cent Peoples Hosp, Dept Pediat, Yichang, Peoples R China
[6] Dangyang Peoples Hosp, Dept Obstet & Gynecol, Dangyang, Peoples R China
[7] Cent Hosp Enshi Tujia & Miao Autonomous Prefecture, Dept Pediat, Enshi, Peoples R China
[8] Hubei Univ Med, Taihe Hosp, Dept Pediat, Shiyan, Peoples R China
[9] Hubei Minzu Univ, Minda Hosp, Dept Pediat, Enshi, Peoples R China
[10] Peoples Hosp Huangpi, Dept Pediat, Wuhan, Peoples R China
[11] China Three Gorges Univ, Affiliated Renhe Hosp, Dept Pediat, Yichang, Peoples R China
[12] Huangshi Cent Hosp, Dept Pediat, Huangshi, Peoples R China
[13] Jingmen Hosp Tradit Chinese Med, Dept Pediat, Jingmen, Peoples R China
[14] Three Gorges Univ Yichang, Peoples Hosp Yichang 2, Hosp 2, Dept Pediat, Yichang, Peoples R China
[15] Jingchu Univ Technol, Jingmen Peoples Hosp, Affiliated Cent Hosp, Dept Pediat, Jingmen, Peoples R China
[16] Huazhong Univ Sci & Technol, Union Jiangbei Hosp, Dept Pediat, Wuhan, Peoples R China
[17] Maternal & Child Hlth Hosp Hanchuan, Dept Pediat, Xiaogan, Peoples R China
[18] Hubei Maternal & Child Hlth Hosp, Dept Pediat Resp Med, Wuhan, Peoples R China
[19] WuHan Asia Gen Hosp, Dept Pediat, Wuhan, Peoples R China
[20] Yangtze Univ, Xiantao Peoples Hosp 1, Dept Pediat, Xiantao, Peoples R China
来源
FRONTIERS IN PEDIATRICS | 2024年 / 12卷
关键词
Mycoplasma pneumoniae; children; prevalence; co-detection; macrolide resistance; BACTERIAL COINFECTION; HOSPITALIZED CHILDREN; INFECTIONS;
D O I
10.3389/fped.2024.1388132
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Aims To investigate the epidemiological and clinical characteristics of children with Mycoplasma pneumoniae pneumonia (MPP) in Hubei, China.Methods We retrospectively analyzed inpatients with MPP from 20 hospitals in Hubei, China from January 2021 to December 2022. The co-detected pathogens of Mycoplasma pneumoniae (M. pneumoniae) were investigated using targeted next-generation sequencing (tNGS), and 23S rRNA gene mutations were analyzed to assess the macrolide resistance.Results M. pneumoniae infected 20.7% of patients with CAP, with cough (96.59%) and fever (80.28%) being the most prevalent symptoms. The infection rates in children younger than 1, 1-2, 3-6, 7-12, and older than 12 years were 6.17%, 19.98%, 26.97%, 43.93%, and 2.95%, respectively. Among 1,349 patients undergoing tNGS, the overall co-detection rate was 59.45%, with Streptococcus pneumoniae (29.30%), Haemophilus influenzae (23.57%), and Human rhinovirus (17.21%) being the most commonly co-detected pathogens. In 635 patients undergoing the 23S rRNA gene mutation test, 86.30% exhibited positive mutations (A2063G, 98.00%; A2064G, 1.50%; A2067G, 0.50%). Despite a significant age difference (P = 0.037) between macrolide-resistant M. pneumoniae and macrolide-sensitive M. pneumoniae groups, there were no significant differences in symptoms, lab data, or disease severity.Conclusions In Hubei Province, the prevalence of exhibited consistent changes during the COVID-19 pandemic. MPP was prevalent year-round, particularly in summer and autumn, with school-age children being more susceptible. Co-detections of viruses and bacteria were frequent in MPP cases, and macrolide resistance exceeded 85%. Ongoing surveillance of M. pneumoniae in children is crucial for understanding the healthcare impact of MPP.
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