The role and mechanism of TXNDC5 in cardio-oncology: Killing two birds with one stone?

被引：0

作者：

An, Na ^{[1
,2
]}

Zhang, Xiaoyu ^{[5
]}

Lin, Hongyuan ^{[8
]}

Xu, Qianqian ^{[6
]}

Dai, Qianqian ^{[2
]}

Kong, Yifan ^{[2
]}

Han, Songjie ^{[2
]}

Li, Xiao ^{[1
,2
]}

Yang, Xinyu ^{[7
]}

Xing, Yanwei ^{[4
]}

Shang, Hongcai ^{[2
,3
,8
]}

机构：

[1] Beijing Univ Chinese Med, DongZhimen Hosp, Beijing, Peoples R China

[2] Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing, Peoples R China

[3] Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R China

[4] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China

[5] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing, Peoples R China

[6] China Acad Chinese Med Sci, Inst Basic Theory Tradit Chinese Med, Beijing, Peoples R China

[7] Beijing Univ Chinese Med, Fangshan Hosp, Beijing, Peoples R China

[8] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Changsha, Peoples R China

来源：

CURRENT PROBLEMS IN CARDIOLOGY | 2025年 / 50卷 / 03期

基金：

中国博士后科学基金;

关键词：

Thioredoxin domain containing 5; Cardio-oncology; Cancer; Cardiotoxicity; Cardiovascular disease; ENDOPLASMIC-RETICULUM STRESS; PROTEIN-DISULFIDE-ISOMERASE; ANTHRACYCLINE CARDIOTOXICITY; OXIDATIVE STRESS; HEART-FAILURE; BREAST-CANCER; SARCOPLASMIC-RETICULUM; SIGNALING PATHWAYS; GASTRIC-CANCER; DOXORUBICIN;

D O I：

10.1016/j.cpcardiol.2024.102951

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardio-oncology has emerged as a new translational and clinical field owing to the growing repertory of cancer therapy. To date, there is a lack of effective pharmacological therapy to target cardiotoxicity. Cardio-oncology, which began by investigating the negative effects of cancer medicines on cardiovascular system, has since grown to include research into the similarities between cardiovascular disease (CVD) and cancer. Thioredoxin domain-containing protein 5 (TXNDC5) belongs to the protein disulfide isomerase (PDI) family. Many diseases, including CVD and cancer, improperly express TXNDC5. This review provides a comprehensive analysis of the expression patterns of TXNDC5 in diseases. It outlines the processes via which TXNDC5 contributes to the advancement of malignant diseases such as CVD and cancer. Additionally, it summarizes prospective therapeutic approaches that can be used to target TXNDC5 for the treatment of these diseases. This will offer novel perspectives for enhancing anticancer therapy and advancing cardio-oncology research and drug development.

引用

页数：10

共 115 条

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