Quantitative and qualitative analysis of seroconversion after one year of vaccination with inactivated SARS-CoV-2 vaccine (CoronaVac®) in healthcare workers: Cross-sectional analytical study

被引：0

作者：

da Silva, Julia Gomes ^{[1
]}

Arruk, Viviana Galimberti ^{[2
,4
]}

Luciano da Veiga, Glaucia Raquel ^{[4
]}

de Alcantara Sousa, Luiz Vinicius ^{[3
]}

Aguiar Alves, Beatriz da Costa ^{[4
]}

Affonso Fonseca, Fernando Luiz ^{[4
,5
]}

van der Heijden Natario, Inneke Marie ^{[2
,4
]}

机构：

[1] Ctr Univ FMABC, Med Course, Santo Andre, SP, Brazil

[2] Ctr Univ FMABC, Dept Pathol, Clin Microbiol Lab, Santo Andre, SP, Brazil

[3] Ctr Univ FMABC, Epidemiol Lab & Data Anal, Santo Andre, SP, Brazil

[4] Ctr Univ FMABC, Clin Anal Lab, Santo Andre, SP, Brazil

[5] UNIFESP Univ Fed Sao Paulo, Dept Pharmaceut Sci, Diadema, SP, Brazil

来源：

JOURNAL OF VIROLOGICAL METHODS | 2025年 / 332卷

关键词：

Inactivated vaccine; SARS-CoV-2; COVID-19; Vaccines; vaccines; Antibodies; Serologic Tests;

D O I：

10.1016/j.jviromet.2024.115067

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A descriptive study was carried out with health professionals in Sao Paulo city. Were included individuals vaccinated with 2 doses of the inactivated vaccine. Demographic, clinical and vaccination information was obtained from professionals with or without comorbidities. Two serological assays were used to identify the presence and quantity of anti-Spike IgG in serum samples. 433 healthy healthcare professionals were included and 58.9 % completed the 4 clinical stages of serological assessment. Among adults and elderly people, 25.2 % had chronic diseases (hypertension 50.5 %, diabetes 10 % and obesity 6.5 %). Most individuals have 95 % protection in the first 3 months after the second dose, and 67.68 % protection after 6 months. Total antibodies ranged from 3 to 10 on the reactivity index, and the anti-RBD IgG levels were high. CoronaVac has a 94 % seroconversion rate after 2 doses and can prevent serious cases and outbreaks of the disease, if used on a large scale.

引用

页数：7

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