Post-Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs

被引：1

作者：

Lancaster, Carly L. ^{[1
,2
,3
]}

Moberg, Kenneth H. ^{[2
]}

Corbett, Anita H. ^{[1
]}

机构：

[1] Emory Coll Arts & Sci, Dept Biol, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Cell Biol, Atlanta, GA USA

[3] Emory Univ Atlanta, Grad Program Biochem Cell & Dev Biol, Atlanta, GA USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-RNA | 2025年 / 16卷 / 02期

关键词：

central dogma; gene expression; messenger RNA; RNA binding protein; translation; 3 UNTRANSLATED REGION; CARBOXYL-TERMINAL DOMAIN; NUCLEAR-PORE COMPLEX; AU-RICH ELEMENTS; BINDING PROTEINS; M(6)A RNA; POLYMERASE-II; QUALITY-CONTROL; CAP STRUCTURE; ZINC-FINGER;

D O I：

10.1002/wrna.70007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In recent years, there has been a growing appreciation for how regulatory events that occur either co- or post-transcriptionally contribute to the control of gene expression. Messenger RNAs (mRNAs) are extensively regulated throughout their metabolism in a precise spatiotemporal manner that requires sophisticated molecular mechanisms for cell-type-specific gene expression, which dictates cell function. Moreover, dysfunction at any of these steps can result in a variety of human diseases, including cancers, muscular atrophies, and neurological diseases. This review summarizes the steps of the central dogma of molecular biology, focusing on the post-transcriptional regulation of gene expression.

引用

页数：18

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