Post-Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs

被引：1
作者：
Lancaster, Carly L. [1 ,2 ,3 ]
Moberg, Kenneth H. [2 ]
Corbett, Anita H. [1 ]
机构：
[1] Emory Coll Arts & Sci, Dept Biol, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Dept Cell Biol, Atlanta, GA USA
[3] Emory Univ Atlanta, Grad Program Biochem Cell & Dev Biol, Atlanta, GA USA
来源：
WILEY INTERDISCIPLINARY REVIEWS-RNA | 2025年 / 16卷 / 02期
关键词：
central dogma; gene expression; messenger RNA; RNA binding protein; translation; 3 UNTRANSLATED REGION; CARBOXYL-TERMINAL DOMAIN; NUCLEAR-PORE COMPLEX; AU-RICH ELEMENTS; BINDING PROTEINS; M(6)A RNA; POLYMERASE-II; QUALITY-CONTROL; CAP STRUCTURE; ZINC-FINGER;
D O I：
10.1002/wrna.70007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In recent years, there has been a growing appreciation for how regulatory events that occur either co- or post-transcriptionally contribute to the control of gene expression. Messenger RNAs (mRNAs) are extensively regulated throughout their metabolism in a precise spatiotemporal manner that requires sophisticated molecular mechanisms for cell-type-specific gene expression, which dictates cell function. Moreover, dysfunction at any of these steps can result in a variety of human diseases, including cancers, muscular atrophies, and neurological diseases. This review summarizes the steps of the central dogma of molecular biology, focusing on the post-transcriptional regulation of gene expression.
引用
收藏
页数：18
相关论文
共 227 条
[1]   Oculopharyngeal muscular dystrophy: Recent advances in the understanding of the molecular pathogenic mechanisms and treatment strategies [J].
Abu-Baker, Aida ;
Rouleau, Guy A. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2007, 1772 (02) :173-185
[2]   Cooperativity in RNA-protein interactions: the complex is more than the sum of its partners [J].
Achsel, Tilmann ;
Bagni, Claudia .
CURRENT OPINION IN NEUROBIOLOGY, 2016, 39 :146-151
[3]   Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway [J].
Adivarahan, Srivathsan ;
Livingston, Nathan ;
Nicholson, Beth ;
Rahman, Samir ;
Wu, Bin ;
Rissland, Olivia S. ;
Zenklusen, Daniel .
MOLECULAR CELL, 2018, 72 (04) :727-+
[4]   RNA Methylation by the MIS Complex Regulates a Cell Fate Decision in Yeast [J].
Agarwala, Sudeep D. ;
Blitzblau, Hannah G. ;
Hochwagen, Andreas ;
Fink, Gerald R. .
PLOS GENETICS, 2012, 8 (06)
[5]   The principal mRNA nuclear export factor NXF1: NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA [J].
Aibara, Shintaro ;
Katahira, Jun ;
Valkov, Eugene ;
Stewart, Murray .
NUCLEIC ACIDS RESEARCH, 2015, 43 (03) :1883-1893
[6]   The molecular architecture of the nuclear pore complex [J].
Alber, Frank ;
Dokudovskaya, Svetlana ;
Veenhoff, Liesbeth M. ;
Zhang, Wenzhu ;
Kipper, Julia ;
Devos, Damien ;
Suprapto, Adisetyantari ;
Karni-Schmidt, Orit ;
Williams, Rosemary ;
Chait, Brian T. ;
Sali, Andrej ;
Rout, Michael P. .
NATURE, 2007, 450 (7170) :695-701
[7]   Mechanisms and Functions of the RNA Polymerase II General Transcription Machinery during the Transcription Cycle [J].
Archuleta, Stephen R. ;
Goodrich, James A. ;
Kugel, Jennifer F. .
BIOMOLECULES, 2024, 14 (02)
[8]   Epitranscriptome: Review of Top 25 Most-Studied RNA Modifications [J].
Arzumanian, Viktoriia A. ;
Dolgalev, Georgii, V ;
Kurbatov, Ilya Y. ;
Kiseleva, Olga, I ;
Poverennaya, Ekaterina, V .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (22)
[9]   FMRP targets distinct mRNA sequence elements to regulate protein expression [J].
Ascano, Manuel, Jr. ;
Mukherjee, Neelanjan ;
Bandaru, Pradeep ;
Miller, Jason B. ;
Nusbaum, Jeffrey D. ;
Corcoran, David L. ;
Langlois, Christine ;
Munschauer, Mathias ;
Dewell, Scott ;
Hafner, Markus ;
Williams, Zev ;
Ohler, Uwe ;
Tuschl, Thomas .
NATURE, 2012, 492 (7429) :382-+
[10]   FMR1 PROTEIN - CONSERVED RNP FAMILY DOMAINS AND SELECTIVE RNA-BINDING [J].
ASHLEY, CT ;
WILKINSON, KD ;
REINES, D ;
WARREN, ST .
SCIENCE, 1993, 262 (5133) :563-566
12345678910