The use of the model organism Caenorhabditis elegans in the investigation of the adverse effects of electronic cigarettes

The use of tobacco products is one of the most preventable risk factors for mortality from a variety of diseases, including cardiovascular, infectious, respiratory, and neoplastic conditions. The use of electronic cigarettes (ECIGs), also known as electronic nicotine delivery devices, has increased significantly in recent years. Nicotine, propylene glycol, and / or glycerine, water, alcohol, flavorings, and other substances are among the many chemicals found in ECIGs that are vaporized and inhaled. A review of the existing literature shows that research dedicated to ECIGs is a rapidly developing and growing field of study. The rationale for the use of ECIGs is that they represent a safer alternative to traditional tobacco products. However, vaping safety profiles are still under development, as this is a relatively recent phenomenon. Various model organisms can be employed to examine the cellular processes that may be altered by exposure to the electronic liquids utilized for vaping. For example, the translucent multicellular eukaryote Caenorhabditis elegans is widely used as a model organism to explain a broad range of biological processes, including aging, stress response, development, and many others. Due to its short lifespan and easy use, C. elegans is an ideal model organism for studying chronic exposure to drugs and environmental toxicology. This review presents a summary of the most recent findings on the impact of electronic cigarettes on the physiological health of this nematode. Preliminary observations made in C. elegans can provide insight into the consequences of exposure to fundamental cellular physiology, which can then be used for future research in humans and mammalian models.