Biochemical and cardiovascular indicators associated with handgrip strength in children and adolescents: A scoping review

Handgrip strength is an indicator of the biological health of children and adolescents. The review's objective is to identify the biochemical and cardiovascular indicators related to handgrip strength. A scoping review was developed, in which the search was conducted in Medline, Web of Science, Science Direct, Scielo, and Sportdiscus from EBSCO. Original research was included if it involved handgrip strength and biochemical or cardiovascular indicators. In the initial search, 15,198 records were identified in databases. 31 studies were selected for this review. These reports identified 36 indicators (29 biochemical and 7 cardiovascular) that had been analyzed for their association with hand grip strength. Blood pressure (n = 10; 32.3%) and homeostatic model assessment for insulin resistance (n = 7; 22.5%) were the most frequently studied characteristics. In the biochemical indicators, a pattern was found in which handgrip strength had a proportional relationship with HDL levels and an inversely proportional relationship with various cardiometabolic scores. No relationship patterns were found in the cardiovascular indicators. (c) 2025 Sociedad Espanola de Medicos de Atencion Primaria (SEMERGEN). Published by Elsevier Espana, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.