Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies Detected 1 Year After BNT162b2 Vaccination in Children

被引：5

作者：

Kobbe, Robin ^{[1
,7
,9
]}

Rau, Cornelius ^{[1
,7
]}

Schulze-Sturm, Ulf ^{[2
]}

Stahl, Felix ^{[3
]}

Fonseca-Brito, Luis ^{[3
]}

Diemert, Anke ^{[4
,5
]}

Luetgehetmann, Marc ^{[6
]}

Addo, Marylyn M. ^{[1
,8
,9
]}

Arck, Petra ^{[4
,5
]}

Weskamm, Leonie M. ^{[1
,8
,9
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Inst Infect Res & Vaccine Dev, Martinistr 52, D-20246 Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Dept Pediat Kinder UKE, Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Inst Immunol, Hamburg, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Div Expt Fetomaternal Med, Dept Obstet & Fetal Med, Hamburg, Germany

[5] Univ Med Ctr Hamburg Eppendorf, Hamburg Ctr Translat Immunol, Hamburg, Germany

[6] Univ Med Ctr Hamburg Eppendorf, Inst Microbiol, Hamburg, Germany

[7] Bernhard Nocht Inst Trop Med, Dept Infect Dis Epidemiol, Hamburg, Germany

[8] Bernhard Nocht Inst Trop Med, Dept Clin Immunol Infect Dis, Hamburg, Germany

[9] German Ctr Infect Res, Hamburg, Germany

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2024年 / 43卷 / 12期

关键词：

mRNA vaccine; IgG4; noninflammatory; SARS-CoV-2; IgG subclass; immune response; children; system immunology; CELLS;

D O I：

10.1097/INF.0000000000004488

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Humoral immune responses after BNT162b2 vaccination are predominantly composed of immunoglobulin (Ig) G1 and IgG3 subclass antibodies. As previously described in adults, S1-specific and receptor-binding domain-specific IgG4 levels increase significantly 1 year after the second BNT162b2 vaccination in children 5-11 years of age. Understanding mRNA vaccine-specific IgG4 responses in all age groups is crucial as more mRNA vaccines will reach licensure in the coming years.

引用

页码：1200 / 1203

页数：4

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