Population-based assessment of major congenital malformations in the United States: smoking risk association

被引：0

作者：

de Andrade, Diancarlos P. ^{[1
,2
]}

Marques, Camila M. ^{[1
,2
]}

Andrade, Dayane C. R. ^{[3
]}

Laureano, Henrique ^{[1
]}

Lenzi, Luana ^{[4
]}

Oliveira, Claudia S. ^{[1
,2
]}

Pereira, Meire E. ^{[1
,2
]}

Figueiredo, Bonald C. ^{[1
,2
,5
,6
]}

机构：

[1] Inst Pesquisa Pele Pequeno Principe, Curitiba, Parana, Brazil

[2] Fac Pequeno Principe, Curitiba, Parana, Brazil

[3] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil

[4] Univ Fed Parana, Dept Anal Clin, Curitiba, Parana, Brazil

[5] Univ Fed Parana, Ctr Genet Mol & Pesquisa Canc Criancas CEGEMPAC, Curitiba, Parana, Brazil

[6] Hosp Pequeno Principe, Curitiba, Parana, Brazil

来源：

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE | 2025年 / 16卷

关键词：

Congenital anomalies; tobacco; pregnancy; club foot; omphalocele; polydactyly; cleft lip; MATERNAL SMOKING; BIRTH-DEFECTS; HEART-DEFECTS; CIGARETTE-SMOKING; TOBACCO CONTROL; FOLIC-ACID; PREGNANCY; PREVALENCE; ANOMALIES; OUTCOMES;

D O I：

10.1017/S2040174425000054

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The incidence of congenital malformations (CM) among non-Hispanic White American (NHWA) mothers was reviewed to identify and evaluate the geographic differences in the most frequent CM subtypes associated with smoking and other risk factors. Data on CM were obtained from 150,775 children (2000-2004) from the Centers for Disease Control and Prevention. Risk factors associated with CM development were the mother's age < 21 and > 35 years, body weight gain during pregnancy, anemia, diabetes mellitus, eclampsia (cases of preeclampsia were omitted), smoking, and alcohol use during pregnancy. Among smoking mothers, the most common CM was omphalocele, club foot, cleft lip, and polydactyly. The highest incidences (CM/10,000 births/year) of observed CM in children of smoking mothers were clubfoot, 25.51 cases (Utah), cleft lip, 22.47 (South Dakota), polydactyly, 21.23 (North Dakota), and omphalocele, 13.14 (Montana). The presence of maternal comorbidities, tobacco and alcohol consumption, and their association with other environmental factors can affect the incidence of CM in NHWA mothers. Further comparisons among the American states regarding the overall changes in CM over the last two decades should uncover crucial outcomes in terms of CM and smoking.

引用

页数：10

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