A comparative analysis of Marburg virus-infected bat and human models from public high-throughput sequencing data

被引:2
作者
Xuan, Do Thi Minh [1 ]
Yeh, I-Jeng [2 ,3 ]
Liu, Hsin-Liang [2 ]
Su, Che-Yu [2 ]
Ko, Ching-Chung [4 ,5 ,6 ]
Ta, Hoang Dang Khoa [7 ]
Jiang, Jia-Zhen [8 ]
Sun, Zhengda [9 ]
Lin, Hung-Yun [10 ,11 ,12 ,13 ,14 ]
Wang, Chih-Yang [7 ,10 ,12 ]
Yen, Meng-Chi [2 ,3 ]
机构
[1] Van Lang Univ, Fac Pharm, 69-68 Dang Thuy Tram St,Ward 13, Ho Chi Minh City 70000, Vietnam
[2] Kaohsiung Med Univ, Dept Emergency Med, Kaohsiung Med Univ Hosp, Kaohsiung 80708, Taiwan
[3] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan
[4] Chi Mei Med Ctr, Dept Med Imaging, Tainan, Taiwan
[5] Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr, Tainan, Taiwan
[6] Natl Sun Yat Sen Univ, Coll Med, Sch Med, Kaohsiung, Taiwan
[7] Taipei Med Univ, Coll Med Sci, Ph D Program Canc Mol Biol & Drug Discovery, Taipei 11031, Taiwan
[8] Fudan Univ, Huashan Hosp North, Dept Emergency, Shanghai 201508, Peoples R China
[9] Kaiser Permanente, Northern Calif Reg Labs, Permanente Med Grp, 1725 Eastshore Hwy, Berkeley, CA 94710 USA
[10] Taipei Med Univ, Grad Inst Canc Biol & Drug Discovery, Coll Med Sci & Technol, Taipei 11031, Taiwan
[11] Taipei Med Univ, Wan Fang Hosp, Canc Ctr, Taipei 11031, Taiwan
[12] Taipei Med Univ, TMU Res Ctr Canc Translat Med, Taipei 11031, Taiwan
[13] Taipei Med Univ, Taipei Med Univ Hosp, Tradit Herbal Med Res Ctr, Taipei 11031, Taiwan
[14] Albany Coll Pharm & Hlth Sci, Pharmaceut Res Inst, Rensselaer, NY 12144 USA
关键词
Marburg virus (MARV); Rousettus aegyptiacus; Homo sapiens; zoonotic disease; bioinformatics; EBOLA-VIRUS; EXPRESSION; HEPATITIS; RESISTANCE; FEATURES; DISEASE; CELLS; HBV;
D O I
10.7150/ijms.100696
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Marburg virus (MARV) disease (MVD) is an uncommon yet serious viral hemorrhagic fever that impacts humans and non-human primates. In humans, infection by the MARV is marked by rapid onset, high transmissibility, and elevated mortality rates, presenting considerable obstacles to the development of vaccines and treatments. Bats, particularly Rousettus aegyptiacus, are suspected to be natural hosts of MARV. Previous research reported asymptomatic MARV infection in bats, in stark contrast to the severe responses observed in humans and other primates. Recent MARV outbreaks highlight significant public health concerns, underscoring the need for gene expression studies during MARV progression. To investigate this, we employed two models from the Gene Expression Omnibus, including kidney cells from Rousettus aegyptiacus and primary proximal tubular cells from Homo sapiens. These models were chosen to identify changes in gene expression profiles and to examine co-regulated genes and pathways involved in MARV disease progression. Our analysis of differentially expressed genes (DEGs) revealed that these genes are mainly associated with pathways related to the complement system, innate immune response via interferons (IFNs), Wnt/beta-catenin signaling, and Hedgehog signaling, which played crucial roles in MARV infection across both models. Furthermore, we also identified several potential compounds that may be useful against MARV infection. These findings offer valuable insights into the mechanisms underlying MARV's pathophysiology and suggest potential strategies for preventing transmission, managing post-infection effects, and developing future vaccines.
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页码:1 / 16
页数:16
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