Ectopic Production of Parathyroid Hormone and Production of Parathyroid Hormone-related Protein in Dedifferentiated Endometrial Carcinoma Induced Severe Hypercalcemia

被引：0

作者：

Ogino, Takeru ^{[1
]}

Watanabe, Hirofumi ^{[1
]}

Yamazaki, Shoko ^{[1
]}

Kurosawa, Megumi ^{[2
]}

Kobayashi, Akiko ^{[2
]}

Imai, Naofumi ^{[1
]}

Taguchi, Takahiro ^{[3
]}

Umezu, Hajime ^{[3
]}

Aida, Ryo ^{[1
]}

Watanabe, Kazuki ^{[1
]}

Otsuka, Tadashi ^{[1
]}

Kabasawa, Hideyuki ^{[4
]}

Kaseda, Ryohei ^{[1
]}

Yamamoto, Suguru ^{[1
]}

Yoshihara, Kosuke ^{[2
]}

Goto, Shin ^{[1
]}

Narita, Ichiei ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Kidney Res Ctr, Div Clin Nephrol & Rheumatol, Niigata, Japan

[2] Niigata Univ, Grad Sch Med & Dent Sci, Dept Obstet & Gynecol, Niigata, Japan

[3] Niigata Univ Med & Dent Hosp, Div Pathol, Niigata, Japan

[4] Niigata Univ, Grad Sch Med & Dent Sci, Dept Clin Nutr Sci, Niigata, Japan

来源：

INTERNAL MEDICINE | 2024年

关键词：

parathyroid hormone; parathyroid hormone-related peptide; dedifferentiated endometrial carcinoma; hypercalcemia; ectopic expression; MALIGNANCY; SECRETION; PATIENT; PTHRP; GENE;

D O I：

10.2169/internalmedicine.3899-24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormonerelated peptide (PTHrP) and, rarely, by parathyroid hormone (PTH) production from tumors. We report a case of severe hypercalcemia in a woman with uterine cancer who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma. Postoperatively, PTH and PTHrP levels normalized but subsequently increased due to metastases. A molecular analysis confirmed the expression of the PTH gene and protein within the tumor, indicating ectopic PTH production. In diagnosing and treating cancers, it is necessary to consider not only PTHrP production but also ectopic PTH production.

引用

页码：1053 / 1059

页数：7

共 29 条

[1] Diagnosis, Pathophysiology and Management of Hypercalcemia in Malignancy: A Review of the Literature
Asonitis, Nikolaos
Angelousi, Anna
Zafeiris, Christos
Lambrou, George I.
Dontas, Ismene
Kassi, Eva
[J]. HORMONE AND METABOLIC RESEARCH, 2019, 51 (12) : 770 - 778
[2] PARANEOPLASTIC HYPERCALCEMIA ASSOCIATED WITH ADENOSQUAMOUS CARCINOMA OF THE ENDOMETRIUM
BULLER, R
TAYLOR, K
BURG, AC
BERMAN, ML
DISAIA, PJ
[J]. GYNECOLOGIC ONCOLOGY, 1991, 40 (01) : 95 - 98
[3] An unusual mediastinal parathyroid carcinoma coproducing PTH and PTHrP: A case report
Cao, Chuangjie
Dou, Chengyun
Chen, Fuqin
Wang, Yan
Zhang, Xiaoli
Lai, Hong
[J]. ONCOLOGY LETTERS, 2016, 11 (06) : 4113 - 4116
[4] Ectopic Production of Parathyroid Hormone in a Patient with Sporadic Medullary Thyroid Cancer
Demura, Masashi
Yoneda, Takashi
Wang, Fen
Zen, Yoh
Karashima, Shigehiro
Zhu, Aoshuang
Cheng, Yuan
Yamagishi, Masakazu
Takeda, Yoshiyu
[J]. ENDOCRINE JOURNAL, 2010, 57 (02) : 161 - 170
[5] Deshaies D, 2019, AM SURGEON, V85, pE45
[6] Paraneoplastic endocrine syndromes
Dimitriadis, Georgios K.
Angelousi, Anna
Weickert, Martin O.
Randeva, Harpal S.
Kaltsas, Gregory
Grossman, Ashley
[J]. ENDOCRINE-RELATED CANCER, 2017, 24 (06) : R173 - R190
[7] PTHrP-Mediated Hypercalcemia: Causes and Survival in 138 Patients
Donovan, Peter J.
Achong, Naomi
Griffin, Katherine
Galligan, John
Pretorius, Carel J.
McLeod, Donald S. A.
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (05) : 2024 - 2029
[8] Eid Wael, 2004, Endocr Pract, V10, P125
[9] Dedifferentiated Endometrial Carcinoma: A Rare Aggressive Neoplasm-Clinical, Morphological and Immunohistochemical Features
Giordano, Giovanna
Ferioli, Elena
Guareschi, Debora
Tafuni, Alessandro
[J]. CANCERS, 2023, 15 (21)
[10] Dedi fferentiated endometrioid adenocarcinoma of the uterus: A case series and review of literature
Goh, C.
Farah, B. L.
Ho, W. Y.
Wong, S. L.
Goh, C. H. R.
Chew, S. H.
Nadarajah, R.
Lim, Y. K.
Ho, T. H.
[J]. GYNECOLOGIC ONCOLOGY REPORTS, 2020, 32

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