Fabrication of MOF-based Nanozyme sensor arrays and their application in disease diagnosis

Nanomaterials with enzyme-like activities are crucial in biosensing, disease diagnosis, and treatment due to their advantages of low costs, ease of synthesis, high stabilities, and tunable activities. Among them, nanozymes based on metal-organic frameworks (MOFs) attract significant attention because of their unique structural characteristics and compositions. In this review, we analyze the regulation mechanisms and catalytic properties of MOFbased nanozymes, focusing on the latest research advancements in sensor development and biomedical applications. Additionally, we briefly explore the potential applications of these nanozymes in smart assistive technologies. Furthermore, we identify the current challenges and limitations, propose viable solutions to address these problems, and position sensors fabricated using MOF-based nanozymes as effective alternatives in disease diagnosis. Ultimately, this review provides guidance for researchers to effectively utilize MOF-based nanozymes in the field of biomedicine.