Granulomatosis with polyangiitis mimicking multisystem pyoderma gangrenosum: A case report

被引：0
作者：
Gormley, Amanda [1 ]
Green, Peter [2 ]
机构：
[1] Dalhousie Univ, Fac Med, 5849 Univ Ave, Halifax, NS B3H 4R2, Canada
[2] Dalhousie Univ, Dept Med, Div Clin Dermatol & Cutaneous Sci, Halifax, NS, Canada
来源：
SAGE OPEN MEDICAL CASE REPORTS | 2024年 / 12卷
关键词：
Granulomatosis with polyangiitis; pyoderma gangrenosum; ANCA-negative; WEGENERS-GRANULOMATOSIS;
D O I：
10.1177/2050313X241304229
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Granulomatosis with polyangiitis, a type of small-medium vessel vasculitis, can pose diagnostic challenges due to its diverse clinical manifestations. We present a case that mimicked multisystem pyoderma gangrenosum with cutaneous ulceration, renal sparing, and antineutrophil cytoplasmic antibody negativity. Although antineutrophil cytoplasmic antibody is positive in approximately 90% of cases of granulomatosis with polyangiitis, its negativity should not exclude the diagnosis. Additionally, pyoderma gangrenosum-like cutaneous ulcers should prompt consideration of granulomatosis with polyangiitis, especially in the context of multisystem disease presentation. This case underscores the importance of maintaining a high suspicion for granulomatosis with polyangiitis in patients presenting with cutaneous ulceration and respiratory tract disease.
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页数：4
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