MiR-19b-3p Serves as a Potential Diagnostic Biomarker for Parkinson's Disease

被引：0
作者：
Wu, Jing [1 ]
Cao, Wei [1 ]
Wei, Wei [1 ]
Zhang, Dandan [1 ]
Li, Xuezhong [1 ]
Wang, Yi [2 ,3 ]
Chen, Xiaopeng [1 ]
机构：
[1] Jiangsu Univ, Affiliated Peoples Hosp, Dept Neurol, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China
[2] Peoples Hosp Jurong City, Dept Neurol, Jurong, Jiangsu, Peoples R China
[3] Jiangsu Univ, Jurong Hosp, Dept Neurol, Jurong, Jiangsu, Peoples R China
来源：
CLINICAL LABORATORY | 2024年 / 70卷 / 12期
关键词：
MiR-19b-3p; Parkinson's disease; inflammatory factors; biomarker; SERUM-LEVELS; EXOSOME; CANCER;
D O I：
10.7754/Clin.Lab.2024.240639
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: Hundreds of miRNAs have been reported to be dysregulated in Parkinson's disease (PD), providing valuable assistance in improving its diagnosis. The purpose of this study was to analyze the expression and diagnostic value of miR-19b-3p in PD patients, as well as its relationship with inflammatory factors. Methods: We recruited 50 PD patients and 50 healthy age- and gender-matched controls and collected demographic data and biochemical parameters from both groups. RT-qPCR was used to detect miR-19b-3p levels in serum. ELISA was used to detect serum levels of TNF-alpha and IL-1 beta. Receiver operating characteristic (ROC) curves were constructed to evaluate the diagnostic value of miR-19b-3p in PD patients. Results: Serum miR-19b-3p expression was downregulated in PD patients compared with healthy controls. A negative correlation was found between miR-19b-3p levels and the MDS-UPDRS score in PD patients (r =-0.686, p < 0.01). In ROC curve analysis, the area under the curve of miR-19b-3p for prediction of PD was 0.779. In PD patients, serum miR-19b-3p levels were negatively correlated with serum IL-1 beta (r =-0.556, p < 0.01) and TNF-alpha levels (r =-0.592, p < 0.01).<br /> Conclusions: Serum miR-19b-3p might serve as a diagnostic and predictive biomarker for PD. The association detected between miR-19b-3p and two common markers of inflammation (IL-1 beta and TNF-alpha) may suggest a role for miR-19b-3p in PD-associated neuroinflammation.
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收藏
页码：2283 / 2289
页数：7
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