Influence of Super-Low-Intensity Microwave Radiation on Mesenchymal Stem Cells

被引：0
作者：
Artamonov, Mikhail Yu. [1 ]
Pyatakovich, Felix A. [2 ]
Minenko, Inessa A. [3 ]
机构：
[1] Penn Med Princeton Hlth, Plainsboro, NJ 08536 USA
[2] Belgorod State Univ, Dept Internal Med, Belgorod 308015, Russia
[3] Sechenov Med Univ, Dept Rehabil, Moscow 119991, Russia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 04期
关键词：
weak electromagnetic field; super-low-intensity microwave field; mesenchymal stem cells; regenerative medicine; tissue regeneration; FREQUENCY ELECTROMAGNETIC-FIELDS; MAGNETIC-FIELDS; OSTEOGENIC DIFFERENTIATION; INFLAMMATORY RESPONSE; EXPOSURE; PROLIFERATION; EXPRESSION; REGENERATION; MECHANISMS; ENHANCE;
D O I：
10.3390/ijms26041705
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mesenchymal stem cells (MSCs) have emerged as a promising tool for regenerative medicine due to their multipotency and immunomodulatory properties. According to recent research, exposing MSCs to super-low-intensity microwave radiation can have a significant impact on how they behave and operate. This review provides an overview of the most recent studies on the effects of microwave radiation on MSCs with power densities that are much below thermal values. Studies repeatedly show that non-thermal mechanisms affecting calcium signaling, membrane transport, mitochondrial activity, along ion channel activation may increase MSC proliferation, differentiation along mesodermal lineages, paracrine factor secretion, and immunomodulatory capabilities during brief, regulated microwave exposures. These bioeffects greatly enhance MSC regeneration capability in preclinical models of myocardial infarction, osteoarthritis, brain damage, and other diseases. Additional study to understand microwave treatment settings, biological processes, and safety assessments will aid in the translation of this unique, non-invasive strategy of activating MSCs with microwave radiation to improve cell engraftment, survival, and tissue healing results. Microwave-enhanced MSC treatment, if shown safe and successful, might have broad relevance as a novel cell-based approach for a variety of regenerative medicine applications.
引用
收藏
页数：14
相关论文
共 80 条
  • [1] Barnes F.S., Greenebaum B., The effects of weak magnetic fields on radical pairs, Bioelectromagnetics, 36, pp. 45-54, (2015)
  • [2] Sun G., Li J., Zhou W., Hoyle R.G., Zhao Y., Electromagnetic interactions in regulations of cell behaviors and morphogenesis, Front. Cell Dev. Biol, 10, (2022)
  • [3] Surkov V., Hayakawa M., Ultra and Extremely Low Frequency Electromagnetic Fields, 486, (2014)
  • [4] Funk R.H., Monsees T., Ozkucur N., Electromagnetic effects–From cell biology to medicine, Prog. Histochem. Cytochem, 43, pp. 177-264, (2009)
  • [5] Barnes F., Greenenbaum B., Some Effects of Weak Magnetic Fields on Biological Systems: RF fields can change radical concentrations and cancer cell growth rates, IEEE Power Electron. Mag, 3, pp. 60-68, (2016)
  • [6] Yalcin S., Erdem G., Biological effects of electromagnetic fields, Afr. J. Biotechnol, 11, pp. 3933-3941, (2012)
  • [7] Sun L.Y., Hsieh D.K., Yu T.C., Chiu H.T., Lu S.F., Luo G.H., Kuo T.K., Lee O.K., Chiou T.W., Effect of pulsed electromagnetic field on the proliferation and differentiation potential of human bone marrow mesenchymal stem cells, Bioelectromagn. J. Bioelectromagn. Soc. Soc. Phys. Regul. Biol. Med. Eur. Bioelectromagn. Assoc, 30, pp. 251-260, (2009)
  • [8] Tsai M.T., Li W.J., Tuan R.S., Chang W.H., Modulation of osteogenesis in human mesenchymal stem cells by specific pulsed electromagnetic field stimulation, J. Orthop. Res, 27, pp. 1169-1174, (2009)
  • [9] Zhang Y., Yan J., Xu H., Yang Y., Li W., Wu H., Liu C., Extremely low frequency electromagnetic fields promote mesenchymal stem cell migration by increasing intracellular Ca 2+ and activating the FAK/Rho GTPases signaling pathways in vitro, Stem Cell Res. Ther, 9, pp. 1-10, (2018)
  • [10] Varani K., Gessi S., Merighi S., Iannotta V., Cattabriga E., Spisani S., Cadossi R., Borea P.A., Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils, Br. J. Pharmacol, 136, pp. 57-66, (2002)
12345678