Research progress on the association between TMAO and vascular calcification in patients with chronic kidney disease

被引：0
|
作者：
Zhang, Yuxin [1 ,2 ,3 ]
Huang, Liangying [1 ,2 ,3 ]
Ou, Santao [1 ,2 ,3 ]
机构：
[1] Southwest Med Univ, Affiliated Hosp, Dept Nephrol, Luzhou, Peoples R China
[2] Sichuan Clin Res Ctr Nephropathy, Luzhou, Peoples R China
[3] Metab Vasc Dis Key Lab Sichuan Prov, Luzhou, Peoples R China
来源：
RENAL FAILURE | 2024年 / 46卷 / 02期
关键词：
Chronic kidney disease; enteric-borne urinary toxin; TMAO; vascular calcification; TRIMETHYLAMINE-N-OXIDE; GLYCATION END-PRODUCTS; SERUM-LEVELS; L-CARNITINE; NLRP3; INFLAMMASOME; OXIDATIVE STRESS; HEALTH; CONTRIBUTES; MICROBIOME; METABOLISM;
D O I：
10.1080/0886022X.2024.2435485
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Vascular calcification (VC) is a common complication in patients with chronic kidney disease (CKD) and a major risk factor for increased cardiovascular mortality in patients with CKD. Its pathology and pathogenesis are complex and have not been fully elucidated. Trimethylamine N-oxide (TMAO) is an enteric-borne uremic toxin that has been found to play a role in the progression of VC. This article mainly reviews the metabolism of TMAO, the relationship between TMAO and VC in CKD patients, and possible treatments for TMAO, aiming to further explore the mechanism of VC occurrence in CKD patients and provide potential diagnostic and treatment strategies.
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页数：10
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