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Patient-Reported Pregnancy Outcomes and Survival in Women with Aortic Valve and/or Aortic Root Replacement
被引:0
作者:
Sinkey, Rachel G.
[1
,2
]
Maxwell, Kathryn S.
[3
]
Padilla, Luz A.
[3
]
Collins, Isabel C.
[4
]
Miller, Vanessa M.
[3
]
Champion, Macie L.
[1
,2
]
Szychowski, Jeff M.
[2
,5
]
Mauchley, Dave
[6
]
Cribbs, Marc G.
[7
]
Wingate, Martha S.
[8
]
Casey, Brian M.
[1
,2
]
Tita, Alan T. N.
[1
,2
]
机构:
[1] Univ Alabama Birmingham, Dept Obstet & Gynecol, 1700 6th Ave S,Women & Infants Ctr 10270, Birmingham, AL 35249 USA
[2] Ctr Womens Reprod Hlth, Birmingham, AL USA
[3] Univ Alabama Birmingham, Dept Surg, Div Cardiothorac Surg, Birmingham, AL USA
[4] Univ Alabama Birmingham, Heersink Sch Med, Sch Med, Birmingham, AL USA
[5] Univ Alabama Birmingham, Sch Publ Hlth, Dept Biostat, Birmingham, AL USA
[6] Univ Washington, Dept Surg, Div Cardiothorac Surg, Seattle, WA USA
[7] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL USA
[8] Univ Alabama Birmingham, Birmingham Sch Publ Hlth, Dept Hlth Policy & Org, Birmingham, AL USA
关键词:
aortic root replacement;
aortic valve replacement;
congenital heart disease;
maternal health;
perinatal outcomes;
racial disparities;
LIFE EXPECTANCY;
HEART-DISEASE;
UNITED-STATES;
RISK;
D O I:
10.1089/jwh.2023.0923
中图分类号:
R1 [预防医学、卫生学];
学科分类号:
1004 ;
120402 ;
摘要:
Background: Our objective was to investigate patient-reported maternal and perinatal outcomes and survival among women undergoing aortic valve and/or aortic root replacement (AVR/ARR).Methods: This was a single-center observational study of U.S. women identified in our surgical/obstetric databases who underwent AVR/ARR between 1967 and 2019. Available, consenting patients participated in a telephone survey detailing patient-reported outcomes. The status of remaining individuals was verified through the Alabama Department of Public Health. Date of death, immediate and underlying cause of death, and death location were abstracted from death certificates.Results: Of 317 patients, 72 were confirmed living, 86 were deceased, and 159 were of unknown status. Mean age at first aortic valve replacement was 43 years. Of patients with known status (n = 158), 33% were Black, and the majority received a mechanical valve (58%). Of 57 participants completing the survey, reported complications included miscarriage (30%), preterm birth (12%), preeclampsia (14%), antepartum maternal intensive care unit admissions (6%), and congenital heart disease in the neonate (8%). Most pregnancies preceded AVR (78%). Among 86 decedents, the average age of death was 52.5 years; the average time from AVR/ARR to death was 7 years. Of those who died, a higher proportion were Black (75%) and had aortic insufficiency (72%).Conclusions: Patients who underwent aortic valve surgery report high rates of maternal and perinatal complications, and death certificate data confirm high rates of racial disparities and death within a decade of surgery. Interventions are urgently needed to improve maternal and perinatal outcomes in individuals with aortic valve disease and to eliminate preventable racial disparities.
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页码:95 / 102
页数:8
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