Liposomal Doxorubicin, Vinblastine and Dacarbazine Plus Consolidation Radiotherapy of Residual Nodal Masses for Frontline Treatment in Older Adults With Advanced Stage Classic Hodgkin Lymphoma: Improved Outcome in a Multi-Center Real-Life Study

被引：0

作者：

Picardi, M. ^{[1
]}

Vincenzi, A. ^{[1
]}

Giordano, C. ^{[1
]}

De Fazio, L. ^{[1
]}

Pugliese, N. ^{[1
]}

Scarpa, A. ^{[1
]}

Vigliar, E. ^{[2
]}

Troncone, G. ^{[2
]}

Russo, D. ^{[3
]}

Mascolo, M. ^{[3
]}

Esposito, G. ^{[3
]}

Prastaro, M. ^{[3
]}

Santoro, C. ^{[3
]}

Esposito, R. ^{[1
]}

Tocchetti, C. G. ^{[4
]}

Mainolfi, C. ^{[3
]}

Fonti, R. ^{[3
]}

Vecchio, S. Del ^{[3
]}

Carchia, M. ^{[2
]}

Quagliano, C. ^{[1
]}

Salemme, A. ^{[1
]}

Damiano, V. ^{[1
]}

Bianco, R. ^{[1
]}

Trastulli, F. ^{[5
]}

Ronconi, F. ^{[5
]}

Annunziata, M. ^{[5
]}

Pane, F. ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Clin Med & Surg, Med Sch, Naples, Italy

[2] Univ Naples Federico II, Dept Publ Hlth, Med Sch Naples, Naples, Italy

[3] Univ Naples Federico II, Dept Adv Biomed Sci, Med Sch, Naples, Italy

[4] Univ Naples Federico II, Dept Translat Med Sci, Med Sch, Naples, Italy

[5] Antonio Cardarelli Hosp Natl Importance, Hematol Unit, Naples, Italy

来源：

HEMATOLOGICAL ONCOLOGY | 2024年 / 42卷 / 06期

关键词：

c-HL; consolidation radiotherapy; elderly patients; MVD; non-pegylated liposomal doxorubicin; CORE-NEEDLE BIOPSY; RESPONSE ASSESSMENT; MANAGEMENT; RADIATION; LYMPHADENOPATHIES; BLEOMYCIN; CYCLES; TRIAL;

D O I：

10.1002/hon.70003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In elderly patients with high-risk classic Hodgkin lymphoma (c-HL), we evaluated the impact of a new modality treatment without bleomycin, that is, liposomal doxorubicin (NPLD)-based regimen plus consolidation radiotherapy of residual nodal masses (RNMs), on overall survival (OS) and progression free survival (PFS). In this retrospective study (2013-2023) conducted in tertiary hospitals in the bay of Naples (Italy), 50 older adults (median age, 69 years; range, 60-89) with advanced stage c-HL received frontline treatment with MVD +/- irradiation. MVD consisted of 25 mg/m2 of NPLD along with standard Vinblastine and Dacarbazine for a total of 6 cycles (twelve iv administrations, every 2 weeks) followed by radiation of RNMs with size >= 2.5 cm at computed tomography. Patients underwent MVD with a median dose intensity of 92%. At 2-deoxy-2[F-18] fluoro-D-glucose positron emission tomography (FDG-PET), 90% of patients (45/50 patients; one failed to perform final FDG-PET due to early death) reached complete responses. Altogether, 17 patients (34%) received consolidation radiotherapy of RNMs with Deauville score >= 3. At 5-year median follow-up, the OS and PFS of the entire population were 87.5% (95% confidence interval [CI], 78.7-97.4) and 81.6% (95% CI, 71.4-93.2), respectively. Eleven patients (22%) experienced grade >= 3 adverse events, and 4 of them required hospitalization. Our data suggest that in older adults with high-risk c-HL NPLD-driven strategy (without bleomycin) plus consolidation radiotherapy (if needed) may be a promising up-front option, to test in phase II clinical trials for improving survival incidence.

引用

页数：13

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