Advancing Cardiac Amyloidosis Care Through Insights from Cardiopulmonary Exercise Testing

被引：4

作者：

Pugliatti, Pietro ^{[1
]}

Trimarchi, Giancarlo ^{[1
,2
]}

Barocelli, Federico ^{[3
]}

Pizzino, Fausto ^{[4
]}

Di Spigno, Francesco ^{[5
]}

Tedeschi, Andrea ^{[5
]}

Piccione, Maurizio Cusma ^{[1
]}

Irrera, Pierangela ^{[1
]}

Aschieri, Daniela ^{[5
]}

Niccoli, Giampaolo ^{[3
,6
]}

Paradossi, Umberto ^{[4
]}

Di Bella, Gianluca ^{[1
]}

机构：

[1] Univ Messina, Dept Clin & Expt Med, I-98100 Messina, Italy

[2] Scuola Super Sant Anna, Interdisciplinary Ctr Hlth Sci, I-56127 Pisa, Italy

[3] Parma Univ Hosp, Cardiol Div, I-43126 Parma, Italy

[4] Osped Cuore G Pasquinucci, Fdn Toscana G Monasterio, I-54100 Massa, Italy

[5] Guglielmo da Saliceto Hosp, Cardiol Unit, Emergency Dept, I-29121 Piacenza, Italy

[6] Univ Parma, Dept Med & Surg, I-43121 Parma, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2024年 / 13卷 / 23期

关键词：

transthyretin amyloid cardiomyopathy; cardiopulmonary exercise testing; heart failure; peak oxygen uptake; HEART-FAILURE; PROGNOSTIC VALUE; DIAGNOSIS; TOLERANCE; MORTALITY; CAPACITY; TIME;

D O I：

10.3390/jcm13237285

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiac amyloidosis, encompassing both transthyretin (ATTR) and light-chain (AL) types, poses considerable challenges in patient management due to its intricate pathophysiology and progressive course. This narrative review elucidates the pivotal role of cardiopulmonary exercise testing (CPET) in the assessment of these patients. CPET is essential for evaluating disease progression by measuring cardio-respiratory performance and providing prognostic insights. This functional test is crucial not only for tracking the disease trajectory, but also for assessing the effectiveness of disease-modifying therapies. Moreover, CPET facilitates the customization of therapeutic strategies based on individual patient performance, enhancing personalized care. By objectively measuring parameters such as peak oxygen uptake (VO2 peak), ventilatory efficiency, and exercise capacity, clinicians can gain a deeper understanding of the degree of functional impairment and make informed decisions regarding treatment initiation, adjustment, and anticipated outcomes. This review emphasizes the importance of CPET in advancing personalized medicine approaches, ultimately striving to improve the quality of life and clinical outcomes for patients with cardiac amyloidosis.

引用

页数：18

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