EORTC-QLQ-C30 and SKINDEX-29 measurement of health-related quality of life in patients with mycosis fungoides and Sézary syndrome: Real-world data in Spanish patients (MICADOS Study)

被引：1

作者：

Matilla, Belen Navarro ^{[1
]}

Gomis, Ma del Mar Onteniente ^{[2
]}

Vallverdu, Ramon M. Pujol ^{[3
]}

Escudero, Andrea Combalia ^{[4
]}

Paz, Irma Zapata ^{[5
]}

Montserrat, Cristina Muniesa ^{[6
]}

Barca, Eva Gonzalez ^{[7
]}

Andujar, Mercedes Morillo ^{[8
]}

Ferriols, Amparo Perez ^{[9
]}

Curto, Ma Concepcion Roman ^{[10
]}

Cabrera, Ricardo Fernandez de Misa ^{[11
]}

Gil, Mercedes Hospital ^{[12
]}

Niebla, Ana Marin ^{[13
]}

Rull, Pablo J. Rios ^{[14
]}

Vicente, Fatima de la Cruz ^{[15
]}

Belloso, Rosa M. Izu ^{[16
]}

Garcia-Sancho, Alejandro Martin ^{[17
]}

Amer, M. Elisabet Parera ^{[18
]}

Mascunano, Raul Cordoba ^{[19
]}

Quiles, Maria Dolores Ramon ^{[20
]}

Carreres, Ana Saus ^{[21
]}

Garcia, Raquel del Campo ^{[22
]}

Machan, Salma ^{[23
]}

Ester, Pablo Viguera ^{[24
]}

Garnelo, Julia Blanco ^{[24
]}

Lopez, Begona Soler ^{[25
]}

Romero, Pablo L. Ortiz ^{[2
]}

机构：

[1] Hosp Univ Puerta de Hierro, Dept Hematol, Madrid, Spain

[2] Univ Complutense Madrid, Hosp Univ 12 Octubre, Sch Med, Dept Dermatol,Inst I 12,CIBERONC, Madrid, Spain

[3] Hosp del Mar, Dept Dermatol, Barcelona, Spain

[4] Hosp Univ Clin & Prov, Dermatol Dept, Barcelona, Spain

[5] Hosp Univ Puerta de Hierro, Oncol Radiat Dept, Madrid, Spain

[6] Hosp Univ Bellvitge, Dermatol Dept, Barcelona, Spain

[7] Inst Catala Oncol Hosp, Hematol Dept, Barcelona, Spain

[8] Hosp Univ Virgen del Rocio, Dermatol Dept, Seville, Spain

[9] Hosp Gen Univ Valencia, Dermatol Dept, Valencia, Spain

[10] Hosp Gen Univ Salamanca, Dermatol Dept, Salamanca, Spain

[11] Hosp Univ Nuestra Senora Candelaria, Dermatol Dept, Santa Cruz De Tenerife, Islas Canarias, Spain

[12] Hosp Univ Puerta de Hierro, Dermatol Dept, Madrid, Spain

[13] Hosp Univ Vall dHebron VHIO, Hematol Dept, Barcelona, Spain

[14] Hosp Univ Nuestra Senora Candelaria, Hematol Dept, Santa Cruz De Tenerife, Islas Canarias, Spain

[15] Hosp Univ Virgen del Rocio, Hematol Dept, Seville, Spain

[16] Hosp Basurto, Dermatol Dept, Bilbao, Spain

[17] Hosp Gen Univ Salamanca, Hematol Dept, Salamanca, Spain

[18] Hosp Son Llatzer, Dermatol Dept, Palma De Mallorca, Islas Baleares, Spain

[19] Hosp Univ Fdn Jimenez Diaz, Hematol Dept, Madrid, Spain

[20] Hosp Clin Univ, Dermatol Dept, Valencia, Spain

[21] Hosp Clin Univ, Hematol Dept, Valencia, Spain

[22] Hosp Son Llatzer, Hematol Dept, Palma De Mallorca, Islas Baleares, Spain

[23] Hosp Univ Fdn Jimenez Diaz, Dermatol Dept, Madrid, Spain

[24] Kyowa Kirin Farmaceut SL, Med Dept, Madrid, Spain

[25] EC BIO SL, Med Dept, Las Rozas, Madrid, Spain

来源：

JEADV CLINICAL PRACTICE | 2022年 / 1卷 / 04期

关键词：

cutaneous T-cell lymphoma; EORTC-QLQ-C30; mycosis fungoides; quality of Life; S & eacute; zary Syndrome; SKINDEX-29; T-CELL LYMPHOMA; CUTANEOUS LYMPHOMA; SEZARY-SYNDROME; INTERNATIONAL SOCIETY; EUROPEAN ORGANIZATION; PROGNOSTIC-FACTORS; UNITED-STATES; PATTERNS; OUTCOMES; VERSION;

D O I：

10.1002/jvc2.39

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background Few studies have explored the impact of cutaneous T-cell lymphoma (CTCL) on health-related quality of life (HRQoL) and compared it to other patients with cancer. Objectives The primary objective of the study was to assess the QoL of patients diagnosed with the mycosis fungoides (MF) and S & eacute;zary syndrome (SS) types of CTCL in Spain. Methods A cross-sectional observational study was completed recruiting adult patients with MF and SS, exploring the European Organisation for Research and Treatment of Cancer-Core Quality of Life Questionnaire, version 3 (EORTC-QLQ-C30v3) and Skindex-29 HRQoL and itching intensity. Results A total of 141 patients [81 males (57.4%) and mean age of 63.6 years (95% CI: 61.4-65.7)], were included. EORTC-QLQ-C30 global health status showed worse scores in CTCL patients compared to healthy population (p < 0.05) and did not differ from other patients with cancer. The physical and role functioning of CTCL patients were better than other patients with cancer (p < 0.05) but worse than healthy population (p < 0.05). The social functioning was similar to other patients with cancer but worse than healthy (p < 0.05). In the global health status, better scores were observed with aging (p = 0.023) and worse scores in patients with Eastern Cooperative Oncology Group (ECOG)-1 versus ECOG-0 (p = 0.01). The Skindex-29 global score was 28.5 (95% CI: 24.8-32.3), being worst at higher clinical stage (p < 0.05) and at higher pruritus intensity (p < 0.001) and better for older patients (p < 0.001). More itching was related to female sex (p = 0.016), younger patients (p = 0.035), higher ECOG (p < 0.05) and higher m-SWAT scores (p = 0.006). Conclusions These results allow mapping HRQoL affectation in CTCL patients. Global health status in MF/SS was like other patients with cancer and worse than the age-matched healthy population. The highest impact in Skindex-29 and EORTC-QLQ-C30 was associated with young age, ECOG, pruritus and disease stage.

引用

页码：438 / 449

页数：12

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