Maturity-Onset Diabetes of the Young (MODY) With HNF1B p.Glu105Lys Mutation Achieving Significant Insulin Reduction on Tirzepatide: A Case Report

被引：0

作者：

Sue, Mihiro ^{[1
]}

Watanabe, Mayu ^{[1
]}

Inoue, Ayumi ^{[1
]}

Katayama, Akihiro ^{[1
]}

Teshigawara, Sanae ^{[2
]}

Matsushita, Yuichi ^{[1
]}

Takeda, Masaya ^{[1
]}

Iseda, Izumi ^{[1
]}

Eguchi, Jun ^{[3
]}

Hida, Kazuyuki ^{[1
]}

机构：

[1] NHO Okayama Med Ctr, Dept Diabetol & Metab, Okayama, Japan

[2] Okayama Saiseikai Gen Hosp, Diabet Ctr, Dept Internal Med, Okayama, Japan

[3] Okayama Univ, Dept Nephrol Rheumatol Endocrinol & Metab, Fac Med Dent & Pharmaceut Sci, Okayama, Japan

来源：

CLINICAL CASE REPORTS | 2025年 / 13卷 / 02期

关键词：

glucagon-like peptide-1 (GLP-1); glucose-dependent insulinotropic polypeptide (GIP); maturity-onset diabetes in young (MODY); tirzepatide; HEPATOCYTE; PROGNOSIS; GENE;

D O I：

10.1002/ccr3.70173

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This report describes the first case of maturity-onset diabetes in young (MODY) with HNF1B mutation started administration of the dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, tirzepatide. A 26-year-old female with a 15-year history of diabetes mellitus was diagnosed with MODY, which is characterized by decreased insulin secretion. She was treated with tirzepatide, which significantly improved her glycemic management; insulin secretion increased the fasting serum C-peptide immunoreactivity from 0.36 to 1.09 ng/mL. The patient discontinued glimepiride, and her total daily insulin dose was reduced from 88 to 4 units. This report highlights the glucose-lowering effects of tirzepatide in a patient with MODY who has the HNF1B p.Glu105Lys mutation.

引用

页数：6

共 39 条

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A. K. Ovsyannikova
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Ovsyannikova, A. K.
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DIABETES THERAPY, 2018, 9 (01) : 413 - 420
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MEDICINE, 2022, 101 (49) : E32139
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CLINICAL DIABETOLOGY, 2015, 4 (04): : 141 - 146
[26] A case report with functional characterization of a HNF1B mutation (p.Leu168Pro) causing MODY5
Yoshida, Kei
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CLINICAL PEDIATRIC ENDOCRINOLOGY, 2021, 30 (04) : 179 - 185
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FRONTIERS IN ENDOCRINOLOGY, 2023, 14
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Wang, Yiting
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JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2017, 31 (07) : 1243 - 1246
[29] Case Report: Identification of an HNF1B p.Arg527Gln mutation in a Maltese patient with atypical early onset diabetes and diabetic nephropathy
Nikolai Paul Pace
Johann Craus
Alex Felice
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BMC Endocrine Disorders, 18
[30] Case Report: Identification of an HNF1B p.Arg527Gln mutation in a Maltese patient with atypical early onset diabetes and diabetic nephropathy
Pace, Nikolai Paul
Craus, Johann
Felice, Alex
Vassallo, Josanne
BMC ENDOCRINE DISORDERS, 2018, 18

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