Cellular Plasticity in Gut and Liver Regeneration

被引:1
作者
Kim, Minwook [1 ,2 ]
Park, Yoojeong [1 ,2 ]
Kim, You Sun [1 ,3 ]
Ko, Sungjin [1 ,2 ]
机构
[1] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Pittsburgh Liver Res Ctr, Pittsburgh, PA 15213 USA
[3] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Coll Med, Seoul, South Korea
关键词
Regeneration; Intestines; Liver; Cellular plasticity; INFLAMMATORY-BOWEL-DISEASE; HEPATIC PROGENITOR CELLS; STEM-CELLS; RAT HEPATOCYTES; IN-VITRO; INTESTINAL REGENERATION; DUCTULAR REACTIONS; CROHNS-DISEASE; MAJOR SOURCE; OVAL CELLS;
D O I
10.5009/gnl240005
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The intestine and liver share a unique regenerative property that sets them apart from other mammalian visceral organs. The intestinal epithelium exhibits rapid renewal, making it one of the fastest renewing tissues in humans. Under physiological conditions, intestinal stem cells within each intestinal crypt continuously differentiate into the different types of intestinal epithelial cells to maintain intestinal homeostasis. However, when exposed to tissue damage or stressful conditions such as inflammation, intestinal epithelial cells in the gastrointestinal tract exhibit plasticity, allowing fully differentiated cells to regain their stem cell properties. Likewise, hepatic epithelial cells possess a remarkable regenerative capacity to restore lost liver mass through proliferationmediated liver regeneration. When the proliferation-mediated regenerative capacity is impaired, hepatocytes and biliary epithelial cells (BECs) can undergo plasticity-mediated regeneration and replenish each other. The transition of mammalian liver progenitor cells to hepatocytes/BECs can be observed under tightly controlled experimental conditions such as severe hepatocyte injury accompanied by the loss of regenerative capacity. In this review, we will discuss the mechanism by which cellular plasticity contributes to the regeneration process and the potential therapeutic implications of understanding and harnessing cellular plasticity in the gut and liver. (Gut Liver 2024;18:949-960)
引用
收藏
页码:949 / 960
页数:12
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