weIMPUTE: a user-friendly web-based genotype imputation platform

被引:0
|
作者
Li, Mingliang [1 ,2 ]
Li, Zhuo [1 ,3 ,4 ]
Liu, Defu [3 ]
Li, Qi [1 ]
Hu, Xiaodong [3 ]
Yu, Jun [2 ]
Lin, Jian [1 ]
Bi, Chunguang [3 ]
Ye, Guanshi [1 ]
Yu, Helong [3 ]
Tang, You [1 ,2 ,3 ]
机构
[1] Jilin Agr Sci & Technol Univ, Elect & Informat Engn Coll, Jilin, Peoples R China
[2] Jilin Inst Chem Technol, Coll Informat & Control Engn, Jilin, Peoples R China
[3] Jilin Agr Univ, Coll Informat Technol, Changchun, Peoples R China
[4] Guangzhou Coll Technol & Business, Sch Engn, Guangzhou, Guangdong, Peoples R China
关键词
imputation; phasing; GUI; genotype; web based; PANEL;
D O I
10.3389/fgene.2025.1532464
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background Genotype imputation is a critical preprocessing step in genome-wide association studies (GWAS), enhancing statistical power for detecting associated single nucleotide polymorphisms (SNPs) by increasing marker size.Results In response to the needs of researchers seeking user-friendly graphical tools for imputation without requiring informatics or computer expertise, we have developed weIMPUTE, a web-based imputation graphical user interface (GUI). Unlike existing genotype imputation software, weIMPUTE supports multiple imputation software, including SHAPEIT, Eagle, Minimac4, Beagle, and IMPUTE2, while encompassing the entire workflow, from quality control to data format conversion. This comprehensive platform enables both novices and experienced users to readily perform imputation tasks. For reference genotype data owners, weIMPUTE can be installed on a server or workstation, facilitating web-based imputation services without data sharing.Conclusion weIMPUTE represents a versatile imputation solution for researchers across various fields, offering the flexibility to create personalized imputation servers on different operating systems.
引用
收藏
页数:6
相关论文
共 50 条
  • [31] A user-friendly platform for developing and accessing grid services
    Morohoshi, Hiroyuki
    Huang, Runhe
    Ma, Jianhua
    INFORMATION SYSTEMS FRONTIERS, 2006, 8 (04) : 255 - 269
  • [32] A user-friendly platform for developing and accessing grid services
    Hiroyuki Morohoshi
    Runhe Huang
    Jianhua Ma
    Information Systems Frontiers, 2006, 8 : 255 - 269
  • [33] A New User-Friendly ATPG Platform for Digital Circuits
    Lipovsky, M.
    Svarc, J.
    Gramatova, E.
    Fiser, P.
    2016 IEEE 19TH INTERNATIONAL SYMPOSIUM ON DESIGN AND DIAGNOSTICS OF ELECTRONIC CIRCUITS & SYSTEMS (DDECS), 2016, : 210 - 213
  • [34] MSIX - A GENERAL AND USER-FRIENDLY PLATFORM FOR RAM ANALYSIS
    PAN, ZJ
    BLEMEL, P
    PROCEEDINGS ANNUAL RELIABILITY AND MAINTAINABILITY SYMPOSIUM, 1992, (SYM): : 501 - 505
  • [35] User-friendly web application for bibliographic material processing
    Belic, K.
    Surla, D.
    ELECTRONIC LIBRARY, 2008, 26 (03): : 400 - 410
  • [36] MiSurv: an Integrative Web Cloud Platform for User-Friendly Microbiome Data Analysis with Survival Responses
    Gu, Won
    Koh, Hyunwook
    Jang, Hyojung
    Lee, Byungho
    Kang, Byungkon
    MICROBIOLOGY SPECTRUM, 2023, 11 (03)
  • [37] CYCLOPEp Builder: Facilitating cyclic peptide and nanotube research through a user-friendly web platform
    Cabezon, Alfonso
    Suarez-Leston, Fabian
    Granja, Juan R.
    Pineiro, Angel
    Garcia-Fandino, Rebeca
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2024, 25 : 91 - 94
  • [38] MyLungRisk calculator: a user-friendly, web-based questionnaire for risk prediction of lung cancer based on the validated Liverpool Lung Project model
    Field, J. K.
    Niaz, A.
    Farley, J.
    Hodge, N.
    Raji, O. Y.
    Duffy, S. W.
    Marcus, M. W.
    Chen, Y.
    LUNG CANCER, 2013, 79 : S18 - S18
  • [39] BIFI: A Taverna plugin for a simplified and user-friendly workflow platform
    Yildiz A.
    Dilaveroglu E.
    Visne I.
    Günay B.
    Sefer E.
    Weinhausel A.
    Rattay F.
    Goble C.A.
    Pandey R.V.
    Kriegner A.
    BMC Research Notes, 7 (1)
  • [40] The ChemicalToolbox: reproducible, user-friendly cheminformatics analysis on the Galaxy platform
    Bray, Simon A.
    Lucas, Xavier
    Kumar, Anup
    Gruening, Bjoern A.
    JOURNAL OF CHEMINFORMATICS, 2020, 12 (01)