Interaction of Myrsinoic acid a with biomembrane models: Differential effects on DPPC and DPPS properties revealed by surface rheology and vibrational spectroscopy

被引：0

作者：

dos Santos, Ana Gabrieli A. ^{[1
]}

Cassas, Fernando ^{[1
]}

dos Santos, Kevin Figueiredo ^{[1
]}

de Medeiros, Livia Soman ^{[1
]}

Veiga, Thiago Andre Moura ^{[1
]}

Caseli, Luciano ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Chem, Diadema, SP, Brazil

来源：

BIOPHYSICAL CHEMISTRY | 2025年 / 322卷

基金：

巴西圣保罗研究基金会;

关键词：

Myrsinoic acid a; Lipid monolayers; PM-IRRAS; Surface rheology; DPPC and DPPS; LANGMUIR MONOLAYERS; LIPID MONOLAYERS; MEMBRANE; ORGANIZATION;

D O I：

10.1016/j.bpc.2025.107439

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study investigates the interactions of Myrsinoic acid A, a natural compound with reported anti-inflammatory and antitumor properties, with lipid monolayers composed of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylserine (DPPS). Utilizing tensiometry, polarization-modulation infrared reflection-absorption spectroscopy (PM-IRRAS), Brewster Angle Microscopy (BAM), and surface rheology, we analyzed how Myrsinoic acid A affects the structural and mechanical properties of these lipid systems. The PM-IRRAS spectra revealed that Myrsinoic acid A induced disorder in the DPPC monolayer, shifting CHI asymmetric stretching peaks and decreasing packing order, while DPPS remained structurally stable. Surface rheology measurements showed reduced elasticity in both lipids, with differential effects on viscosity: a decrease for DPPC and an increase for DPPS, indicating varied molecular interactions. BAM images confirmed that DPPC maintained a homogeneous morphology, while DPPS displayed aggregate formation, suggesting distinct lipid-drug interactions. These findings highlight the importance of lipid composition in modulating the effects of Myrsinoic acid A on membrane properties, providing insights into its potential therapeutic applications in targeting tumorigenic versus non-tumorigenic cells.

引用

页数：8