The aryl hydrocarbon receptor: A crucial mediator in ocular disease pathogenesis and therapeutic target

被引：0

作者：

Ji, Juanjuan ^{[1
]}

Xiong, Chanyu ^{[1
]}

Yang, Huining ^{[1
]}

Jiang, Zhilin ^{[1
]}

Zhang, Yun ^{[1
]}

Wang, Xiao ^{[1
]}

Yu, Tianshu ^{[1
]}

Li, Qiong ^{[1
]}

Zhu, Shikai ^{[2
]}

Zhou, Yu ^{[1
]}

机构：

[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Genome Sequencing Ctr, Sch Med,Dept Lab Med,Sichuan Prov Key Lab Human Di, Chengdu, Peoples R China

[2] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Organ Transplant Ctr, Sch Med, Chengdu, Peoples R China

来源：

EXPERIMENTAL EYE RESEARCH | 2024年 / 249卷

基金：

中国国家自然科学基金;

关键词：

AHR1; retina2; RPE3; chroid4; Eye disease 5; Immune response 6; REGULATORY T-CELLS; EXPERIMENTAL AUTOIMMUNE UVEITIS; OPEN-ANGLE GLAUCOMA; MACULAR DEGENERATION; CHOROIDAL NEOVASCULARIZATION; MATRIX METABOLISM; OXIDATIVE STRESS; LINKED PROTEIN; ACTIVATION; AIPL1;

D O I：

10.1016/j.exer.2024.110144

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The aryl hydrocarbon receptor (AHR) is a pivotal nuclear receptor involved in mediating cellular responses to a wide range of environmental pollutants and endogenous ligands. AHR plays a central role in regulating essential physiological processes, including xenobiotic metabolism, immune response modulation, cell cycle control, tumorigenesis, and developmental events. Recent studies have identified AHR as a critical mediator and a potential therapeutic target in the pathogenesis of ocular diseases. This review provides a thorough analysis of the various functions of AHR signalling in the ocular environment, with a specific emphasis on its effects on the retina, retinal pigment epithelium (RPE), choroid, and cornea. We provide a detailed discussion on the molecular mechanisms through which AHR integrates environmental and endogenous signals, influencing the development and progression of age-related macular degeneration (AMD), retinitis pigmentosa, uveitis, and other major ocular disorders. Furthermore, we evaluate the therapeutic potential of modulating AHR activity through novel ligands and agonists as a strategy for treating eye diseases. Understanding the molecular mechanisms of AHR in ocular tissues may facilitate the development of AHR-targeted therapies, which is crucial for addressing the pressing clinical demand for novel treatment strategies in ocular diseases.

引用

页数：9

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