Versatile synthesis of 2-functionalized dihydrothiazolo[2,3-b]quinazolines through regioselective electrophilic intramolecular heterocyclization of 3-alkenyl-2-thioxoquinazolin-4-ones

被引：0
|
作者：
Kut, Diana Zh. [1 ]
Kut, Mykola M. [1 ]
Ostapchuk, Eugeniy M. [2 ]
Onysko, Mikhajlo Yu. [1 ]
Onys'ko, Petro P. [3 ]
Lendel, Vasil G. [1 ]
机构：
[1] Uzhgorod Natl Univ, Uzhgorod, Ukraine
[2] Taras Shevchenko Natl Univ Kyiv, Kiev, Ukraine
[3] Natl Acad Sci Ukraine, Inst Organ Chem, Kiev, Ukraine
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2024年 / 199卷 / 7-9期
关键词：
Thioxoquinazolinones; thiazolo[2,3-b]quinazolines; electrophilic cyclization; regioselectivity; organoselenium; organotellurium; CYCLIZATION;
D O I：
10.1080/10426507.2024.2416210
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Electrophilic intramolecular heterocyclizations of 3-alkenyl-2-thioxoquinazolin-4-ones, induced by halogens, NBS, sulfuryl chloride, protic acids, selenium, or tellurium halides, proceed with high regioselectivity. This process leads to the formation of 2-functionalized dihydrothiazolo[2,3-b]quinazolines, showcasing the versatility and reliability of this synthetic route across various electrophilic reagents. [Graphics]
引用
收藏
页码：675 / 682
页数：8
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