Versatile synthesis of 2-functionalized dihydrothiazolo[2,3-b]quinazolines through regioselective electrophilic intramolecular heterocyclization of 3-alkenyl-2-thioxoquinazolin-4-ones

被引：0

作者：

Kut, Diana Zh. ^{[1
]}

Kut, Mykola M. ^{[1
]}

Ostapchuk, Eugeniy M. ^{[2
]}

Onysko, Mikhajlo Yu. ^{[1
]}

Onys'ko, Petro P. ^{[3
]}

Lendel, Vasil G. ^{[1
]}

机构：

[1] Uzhgorod Natl Univ, Uzhgorod, Ukraine

[2] Taras Shevchenko Natl Univ Kyiv, Kiev, Ukraine

[3] Natl Acad Sci Ukraine, Inst Organ Chem, Kiev, Ukraine

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2024年 / 199卷 / 7-9期

关键词：

Thioxoquinazolinones; thiazolo[2,3-b]quinazolines; electrophilic cyclization; regioselectivity; organoselenium; organotellurium; CYCLIZATION;

D O I：

10.1080/10426507.2024.2416210

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Electrophilic intramolecular heterocyclizations of 3-alkenyl-2-thioxoquinazolin-4-ones, induced by halogens, NBS, sulfuryl chloride, protic acids, selenium, or tellurium halides, proceed with high regioselectivity. This process leads to the formation of 2-functionalized dihydrothiazolo[2,3-b]quinazolines, showcasing the versatility and reliability of this synthetic route across various electrophilic reagents. [Graphics]

引用

页码：675 / 682

页数：8

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