Decoding stress granules dynamics: Implications for neurodegenerative disease

被引：0

作者：

Wang, Zixuan ^{[1
,3
,5
,6
]}

Yang, Chenyi ^{[2
,3
,4
,5
,6
]}

Wang, Xinyi ^{[2
,3
,4
,5
]}

Lyu, Wenyuan ^{[1
,7
]}

Liao, Huihui ^{[1
,3
,5
,6
]}

Liu, Xing ^{[1
,3
,5
,6
]}

Liu, Huan ^{[1
,3
,5
,6
]}

Zhang, Jingwei ^{[1
,3
,5
,6
]}

Shen, Huai ^{[1
,3
,5
,6
]}

Zhang, Lin ^{[1
,3
,5
,6
]}

Wang, Haiyun ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Tianjin Med Univ, Third Cent Clin Coll, Tianjin 300170, Peoples R China

[2] Nankai Univ, Tianjin 300071, Peoples R China

[3] Third Cent Hosp Tianjin, Dept Anesthesiol, Tianjin 300170, Peoples R China

[4] Nankai Univ, Cent Hosp 3, Tianjin 300170, Peoples R China

[5] Tianjin Key Lab Extracorporeal Life Support Crit D, Tianjin 300170, Peoples R China

[6] Artificial Cell Engn Technol Res Ctr, Tianjin 300170, Peoples R China

[7] Shandong Univ Qingdao, Qilu Hosp, Qingdao 266000, Peoples R China

来源：

PROGRESS IN NEUROBIOLOGY | 2025年 / 248卷

基金：

中国国家自然科学基金;

关键词：

Stress granules; Dynamics; Neurodegenerative disease; Targeted therapy; AMYOTROPHIC-LATERAL-SCLEROSIS; FRONTOTEMPORAL LOBAR DEGENERATION; EUKARYOTIC TRANSLATION INITIATION; TAU-MEDIATED NEURODEGENERATION; NUCLEAR IMPORT RECEPTOR; RNA-BINDING PROTEINS; PRION-LIKE DOMAINS; PHASE-SEPARATION; MESSENGER-RNA; TDP-43;

D O I：

10.1016/j.pneurobio.2025.102758

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stress granules (SGs) are membrane-less cytoplasmic structures formed by cells in response to external stress, primarily composed of mRNA and proteins. The dynamic properties of their assembly, maintenance, and disassembly play crucial roles in cellular homeostasis. Recent studies have increasingly revealed that aberrations in SGs dynamics are closely related to the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. This review summarizes the latest research progress on SGs dynamics in neurodegenerative diseases. It begins with an overview of the basic biological characteristics of SGs and their functions in neurons, followed by an in-depth exploration of the mechanisms and regulatory pathways of SGs dynamics. The review then summarizes potential therapeutic strategies targeting SGs dynamics abnormalities, particularly through small molecule drugs to modulate SGs formation and disassembly, aiming to delay or halt the progression of neurodegenerative diseases. The review also highlights the application prospects of these interventions in treating neurodegenerative diseases. Finally, the review introduces current techniques used to study SGs dynamics, discussing their advantages, limitations, and future development possibilities. This review aims to provide researchers with a comprehensive perspective to advance the understanding and clinical application of SGs dynamics in the field of neurodegenerative diseases.

引用

页数：14

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