Frontal neurodegeneration associated with Frontal Assessment Battery in early Alzheimer's disease

被引：2

作者：

Terada, Tatsuhiro ^{[1
,2
]}

Kubota, Manabu ^{[3
,4
]}

Miyata, Jun ^{[3
,5
]}

Obi, Tomokazu ^{[1
]}

Takashima, Hirotsugu ^{[1
,2
]}

Matsudaira, Takashi ^{[1
,2
]}

Bunai, Tomoyasu ^{[2
]}

Ouchi, Yasuomi ^{[2
]}

Murai, Toshiya ^{[3
]}

机构：

[1] Shizuoka Inst Epilepsy & Neurol Disorders, Dept Neurol, 886 Urushiyama,Aoi Ku, Shizuoka 4208688, Japan

[2] Hamamatsu Univ, Sch Med, Inst Photon Med, Preeminent Bioimaging Res,Dept Biofunct Imaging, 1-20-1 Handayama Higashi Ku, Hamamatsu 4313192, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Psychiat, 54 Shogoin-Kawahara Cho,Sakyo Ku, Kyoto 6068507, Japan

[4] Natl Inst Quantum & Radiol Sci & Technol, Natl Inst Radiol Sci, Dept Funct Brain Imaging, Brain Disorder Translat Res Grp, 4-9-1 Anagawa,Inage Ku, Chiba 2638555, Japan

[5] Aichi Med Univ, Dept Psychiat, 1-1 Karimata, Nagakute, Aichi 4801195, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2024年 / 467卷

关键词：

Alzheimer's disease (AD); Amnestic mild cognitive impairments (aMCI); Frontal Assessment Battery (FAB); Voxel-based morphometry (VBM); F-18]FDG; C-11]PiB; MILD COGNITIVE IMPAIRMENT; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DEMENTIA; RECOMMENDATIONS; CONNECTIVITY; WORKGROUPS; VARIANT; SCALE; PET;

D O I：

10.1016/j.jns.2024.123327

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The Frontal Assessment Battery (FAB) is widely used to assess executive dysfunction in patients with amnestic mild cognitive impairments due to Alzheimer's disease (aMCI-AD), but its neurobiological meaning is unclear. To elucidate this, we examined the relationship between the FAB score and three key imaging biomarkers: gray matter volume, amyloid-beta (A beta) deposition, and glucose metabolism. Methods: Twenty A beta- and tau-positive aMCI-AD patients and age-matched controls underwent structural magnetic resonance imaging and positron emission tomography with [C-11]PiB and [F-18]FDG. Voxel-based morphometry and statistical parametric mapping analyses were performed to elucidate the relationships between FAB scores and regional gray matter volume, [C-11]PiB uptake for A beta deposition, and [F-18]FDG uptake for glucose metabolism. Results: FAB scores were significantly lower in aMCI-AD than in controls (p < 0.001). In aMCI-AD, FAB was significantly correlated with right inferior frontal gray matter volume and right medial and left middle frontal glucose metabolism (family-wise error p < 0.05). However, there was no correlation between A beta deposition and FAB (family-wise error p < 0.05). Conclusions: The decreased FAB score is linked more with frontal-lobe neurodegeneration than with A beta pathology in aMCI-AD. The FAB could be an early marker for neurodegeneration related to frontal-lobe executive dysfunction.

引用

页数：10

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