Clinical value of serum miR-214-3p expression in the diagnosis of type 2 diabetes mellitus and prediction of its chronic complications

被引：0
作者：
Meng Ding [1 ]
Siyu Yang [2 ]
Junli Li [3 ]
Lie Ma [4 ]
Cunyou Xiong [5 ]
Jie Zhang [6 ]
机构：
[1] Department of Clinical Laboratory, The Second Hospital of Nanjing, Nanjing Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Nanjing
[2] General Practice, The First Affiliated Hospital of Jilin University, Jilin
[3] Endocrine and Metabolic Diseases Department, Yantai Mountain Hospital, Yantai
[4] Endocrinology Department, People’s Hospital of Rongchang District, Chongqing
[5] General Practice Department, Longhua District, People’s Hospital, Community Service Center, Minzhi Street, Shenzhen
[6] Endocrinology Department, Nanjing Luhe People’s Hospital, No. 28, Yan’an Road, Luhe District, Nanjing
来源：
BMC Endocrine Disorders | / 25卷 / 1期
关键词：
Chronic complications; Diagnosis; miR-214-3p; Type 2 diabetes mellitus;
D O I：
10.1186/s12902-025-01916-1
中图分类号：
学科分类号：
摘要：
Background: The majority of diabetes cases fall into type 2 diabetes mellitus (T2DM), which is prone to chronic complications that have a long-term impact on patients. The aim of this study was to investigate the diagnostic potential of miR-214-3p in T2DM and its predictive value for chronic complications, providing a novel biomarker for the disease. Methods: A total of 156 patients with T2DM and 80 non-T2DM individuals were included. Serum miR-214-3p levels were measured by real-time reverse transcription quantitative PCR (RT-qPCR). The correlation of miR-214-3p with hemoglobin A1c (HbA1c) and low-density lipoprotein cholesterol (LDL-C) was analyzed by Spearman’s rank correlation. The clinical value of miR-214-3p in T2DM was evaluated using the receiver operating characteristic (ROC) curve and logistic regression analysis. Results: The serum levels of miR-214-3p were decreased in T2DM patients compared to non-T2DM individuals. A negative correlation was identified between miR-214-3p expression and the levels of HbA1c and LDL-C. miR-214-3p could effectively differentiate T2DM patients from non-T2DM individuals with the area under ROC curve (AUC) of 0.884. Patients with low miR-214-3p expression had a higher incidence of chronic complications. The AUC for miR-214-3p in differentiating between T2DM patients with and without complications was 0.832. Low expression of miR-214-3p was a risk factor linked to the development of chronic complications in patients with T2DM. Conclusion: Serum miR-214-3p was downregulated in T2DM and could differentiate T2DM patients from non-T2DM individuals. miR-214-3p was a promising biomarker for predicting the chronic complications of T2DM. © The Author(s) 2025.
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