On-Demand Continuous Flow Synthesis of Pentafluorosulfanyl Chloride (SF5Cl) Using a Custom-Made Stirring Packed-Bed Reactor

被引：0

作者：

Peyrical, Lauriane C. ^{[1
]}

Mabit, Thibaud ^{[1
]}

Kairouz, Vanessa ^{[1
]}

Charette, Andre B. ^{[1
]}

机构：

[1] Univ Montreal, Ctr Continuous Flow Synth, Dept Chem, FRQNT Ctr Green Chem & Catalysis, 1375 Ave Therese Lavoie Roux, Montreal, PQ H2V 0B3, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2025年 / 31卷 / 14期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

custom-made stirring packed-bed reactor; continuous flow chemistry; pentafluorosulfanyl; radical reactions; GAS GENERATION; TRIFLUOROMETHYL; SUBSTITUENTS; CONVENIENT; CHEMISTRY;

D O I：

10.1002/chem.202404039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pentafluorosulfanyl (SF5-) group has been the subject of a surge of interest in the past decade, but there is still little practicality associated with its synthesis and installation. Herein is reported the first continuous flow synthesis of pentafluorosulfanyl chloride (SF5Cl), the most common reagent for the synthesis of SF5-substituted compounds. The synthesis is based on inexpensive and easy-to-handle reagents: sulfur powder (S8), trichloroisocyanuric acid (TCCA) and potassium fluoride (KF). To this end, a custom-made stirring reactor was designed to allow for fast, safe, and highly efficient on-demand synthesis of SF5Cl. The resulting SF5Cl solution is showcased in the radical addition on alkynes in a telescoped fashion.

引用

页数：6

共 2 条

[1] Enzymatic synthesis of a series of alkyl esters using novozyme 435 in a packed-bed, miniaturized, continuous flow reactor
Woodcock, L. L.
Wiles, C.
Greenway, G. M.
Watts, P.
Wells, A.
Eyley, S.
BIOCATALYSIS AND BIOTRANSFORMATION, 2008, 26 (06) : 501 - 507
[2] Enzymatic Synthesis of Ethyl Esters from Waste Oil Using Mixtures of Lipases in a Plug-Flow Packed-Bed Continuous Reactor
Poppe, Jakeline Kathiele
Matte, Carla Roberta
de Freitas, Vitoria Olave
Fernandez-Lafuente, Roberto
Rodrigues, Rafael C.
Zichia Ayub, Marco Antonio
BIOTECHNOLOGY PROGRESS, 2018, 34 (04) : 952 - 959

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