Impact of Endocrine Disrupting Pesticide Use on Obesity: A Systematic Review

被引:2
作者
Perez-Bermejo, Marcelino [1 ]
Barrezueta-Aguilar, Cristian [2 ]
Perez-Murillo, Javier [1 ]
Ventura, Ignacio [3 ]
Legidos-Garcia, Maria Ester [1 ]
Tomas-Aguirre, Francisco [1 ]
Tejeda-Adell, Manuel [1 ]
Martinez-Peris, Miriam [1 ]
Mari-Beltran, Belen [1 ]
Murillo-Llorente, Maria Teresa [1 ]
机构
[1] Catholic Univ Valencia San Vicente Martir, Sch Med & Hlth Sci, SONEV Res Grp, C-Quevedo 2, Valencia 46001, Spain
[2] Catholic Univ Valencia San Vicente Martir, Sch Med & Hlth Sci, Dept Nutr, C-Quevedo 2, Valencia 46001, Spain
[3] Catholic Univ Valencia San Vicente Martir, Sch Med & Hlth Sci, Mol & Mitochondrial Med Res Grp, C-Quevedo 2, Valencia 46001, Spain
关键词
pesticide; endocrine disruptor; overweight; obesity; PERSISTENT ORGANIC POLLUTANTS; DIET-INDUCED ADIPOSITY; INSULIN-RESISTANCE; WEIGHT-GAIN; DICHLOROPHENOL PESTICIDES; URINARY CONCENTRATIONS; PROMOTES ADIPOGENESIS; CHRONIC EXPOSURE; ENERGY-BALANCE; ASSOCIATION;
D O I
10.3390/biomedicines12122677
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background/Objectives: Endocrine disruptors are substances capable of altering the functions of the endocrine system. There is evidence that some pesticides can be endocrine disruptors and, among some of their effects, we find alterations in pubertal development and in the function of the thyroid gland, which could be related to a greater tendency of obesity. The aim was to evaluate the evidence from clinical and preclinical studies on the association between pesticides used in agriculture and found in plant-based foods with overweight/obesity. Methods: This is a systematic review of articles on the impact of the use of endocrine disrupting pesticides on obesity, conducted according to the PRISMA-2020 guidelines. Results: There was evidence that some pesticides, such as chlorpyrifos, pyrethroids, and neonicotinoids, may promote obesity and other anthropometric changes by altering lipid and glucose metabolism, modifying genes, or altering hormone levels such as leptin. Other studies suggest that perinatal exposure to chlorpyrifos or pesticides such as vinclozolin may alter lipid metabolism and promote weight gain in adulthood, whereas other pesticides such as boscalib, captan, thiacloprid, and ziram were not associated with changes in weight. Exposure to pesticides such as vinclozolin may be associated with a higher prevalence of overweight/obesity in later generations. Conclusions: The few studies that do not show these associations have methodological limitations in data collection with confounding variables. Further studies are needed to provide more and higher quality evidence to determine the true effect of these substances on obesity.
引用
收藏
页数:18
相关论文
共 50 条
[41]   Impact of exercise training duration on obesity and cardiometabolic biomarkers: a systematic review [J].
Rai, Richa Hirendra ;
Singh, Ram B. ;
Mehta, Vishal ;
Sakshi ;
Asif, Mohd ;
Goyal, Kajal ;
Balodhi, Apoorva ;
Manglik, Palak ;
Sharma, Abhishek ;
Chahal, Aksh .
JOURNAL OF DIABETES AND METABOLIC DISORDERS, 2023, 22 (01) :155-174
[42]   Endocrine consequences of childhood obesity: a narrative review [J].
Badr, Maroun ;
El-Rabaa, Ghazwa ;
Freiha, Marianne ;
Kedzia, Andrzej ;
Niechcial, Elzbieta .
FRONTIERS IN ENDOCRINOLOGY, 2025, 16
[43]   Behavioral factors influencing childhood obesity: a systematic review and meta-analysis [J].
Poorolajal, Jalal ;
Sahraei, Fatemeh ;
Mohamdadi, Younes ;
Doosti-Irani, Amin ;
Moradi, Leila .
OBESITY RESEARCH & CLINICAL PRACTICE, 2020, 14 (02) :109-118
[44]   Peer review of the pesticide risk assessment of the active substance S-metolachlor excluding the assessment of the endocrine disrupting properties [J].
Alvarez, Fernando ;
Arena, Maria ;
Auteri, Domenica ;
Binaglia, Marco ;
Castoldi, Anna Federica ;
Chiusolo, Arianna ;
Colagiorgi, Angelo ;
Colas, Mathilde ;
Crivellente, Federica ;
De Lentdecker, Chloe ;
De Magistris, Isabella ;
Egsmose, Mark ;
Fait, Gabriella ;
Ferilli, Franco ;
Gouliarmou, Varvara ;
Nogareda, Laia Herrero ;
Ippolito, Alessio ;
Istace, Frederique ;
Jarrah, Samira ;
Kardassi, Dimitra ;
Kienzler, Aude ;
Lanzoni, Anna ;
Lava, Roberto ;
Leuschner, Renata ;
Linguadoca, Alberto ;
Lythgo, Christopher ;
Magrans, Oriol ;
Mangas, Iris ;
Miron, Ileana ;
Molnar, Tunde ;
Padovani, Laura ;
Panzarea, Martina ;
Parra Morte, Juan Manuel ;
Rizzuto, Simone ;
Serafimova, Rositsa ;
Sharp, Rachel ;
Szentes, Csaba ;
Szoradi, Andras ;
Terron, Andrea ;
Theobald, Anne ;
Tiramani, Manuela ;
Vianello, Giorgia ;
Villamar-Bouza, Laura .
EFSA JOURNAL, 2023, 21 (02)
[45]   The impact of obesity epidemic on type 2 diabetes in children and adolescents: A systematic review and meta-analysis [J].
He, Qing-Xia ;
Zhao, Li ;
Tong, Ji-Shuang ;
Liang, Xiao-Yue ;
Li, Ri-Na ;
Zhang, Ping ;
Liang, Xiao-Hua .
PRIMARY CARE DIABETES, 2022, 16 (06) :736-744
[46]   Obesity determinants: a systematic review [J].
Jelassi, Mariem ;
Ben Miled, Slimane ;
Ben Saoud, Narjes Bellamine ;
Demongeot, Jacques .
PROCEEDINGS OF 2015 THIRD IEEE WORLD CONFERENCE ON COMPLEX SYSTEMS (WCCS), 2015,
[47]   Physical exercise consequences on memory in obesity: A systematic review [J].
Leoni De Sousa, Ricardo Augusto ;
Santos, Leticia Gomes ;
Lopes, Paulo Mauricio ;
Ribeiro Cavalcante, Bruno Raphael ;
Improta-Caria, Alex Cleber ;
Cassilhas, Ricardo Cardoso .
OBESITY REVIEWS, 2021, 22 (10)
[48]   Pediatric obesity and periodontal disease: A systematic review of the literature [J].
Katz, Joseph ;
Bimstein, Enrique .
QUINTESSENCE INTERNATIONAL, 2011, 42 (07) :595-599
[49]   Obesity and its health impact in Africa: a systematic review [J].
Adeboye, Bridget ;
Bermano, Giovanna ;
Rolland, Catherine .
CARDIOVASCULAR JOURNAL OF AFRICA, 2012, 23 (09) :512-521
[50]   Obesity and periodontitis: systematic review and meta-analysis [J].
de Moura-Grec, Patricia Garcia ;
Marsicano, Juliane Avansini ;
Paz de Carvalho, Cristiane Alves ;
de Carvalho Sales-Peres, Silvia Helena .
CIENCIA & SAUDE COLETIVA, 2014, 19 (06) :1763-1772