(3-Cyclodextrin-based polyelectrolyte complexes for drug delivery

被引：1

作者：

Zhao, Rongrong ^{[1
]}

Tang, Bo ^{[1
]}

Xu, Zhuoya ^{[1
]}

Fang, Guihua ^{[1
]}

机构：

[1] Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2025年 / 534卷

基金：

中国国家自然科学基金;

关键词：

Polyelectrolyte complexes; Anionic (3-Cyclodextrin; Cationic (3-Cyclodextrin; Dosage forms; Drug delivery; ETHER-BETA-CYCLODEXTRIN; IN-VITRO; SIRNA DELIVERY; GENE DELIVERY; CHOROIDAL NEOVASCULARIZATION; CHITOSAN NANOPARTICLES; POLYETHYLENIMINE PEI; CONTROLLED-RELEASE; INCLUSION COMPLEX; POLYMER;

D O I：

10.1016/j.ccr.2025.216581

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Polyelectrolyte complexes represent versatile formulations arising from electrostatic interactions between oppositely charged polymers. (3-Cyclodextrin ((3-CD), a cyclic oligosaccharide characterized by its truncated coneshaped structure, cannot inherently form such complexes due to its neutral surface. This article introduces anionic, cationic and zwitterionic (3-CD-based polyelectrolytes, detailing their synthesis routes and unique properties. Furthermore, it summarizes the diverse dosage forms, such as nanoparticles, nanocapsules, nanofibers, and hydrogels, that can be fabricated using (3-CD-based polyelectrolyte complexes. Additionally, the in vivo applications of these complexes in drug delivery systems, encompassing oral delivery, local drug delivery, and nucleic acid drug delivery, are systematically discussed.

引用

页数：21

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