(3-Cyclodextrin-based polyelectrolyte complexes for drug delivery

被引：0
作者：
Zhao, Rongrong [1 ]
Tang, Bo [1 ]
Xu, Zhuoya [1 ]
Fang, Guihua [1 ]
机构：
[1] Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2025年 / 534卷
基金：
中国国家自然科学基金;
关键词：
Polyelectrolyte complexes; Anionic (3-Cyclodextrin; Cationic (3-Cyclodextrin; Dosage forms; Drug delivery; ETHER-BETA-CYCLODEXTRIN; IN-VITRO; SIRNA DELIVERY; GENE DELIVERY; CHOROIDAL NEOVASCULARIZATION; CHITOSAN NANOPARTICLES; POLYETHYLENIMINE PEI; CONTROLLED-RELEASE; INCLUSION COMPLEX; POLYMER;
D O I：
10.1016/j.ccr.2025.216581
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Polyelectrolyte complexes represent versatile formulations arising from electrostatic interactions between oppositely charged polymers. (3-Cyclodextrin ((3-CD), a cyclic oligosaccharide characterized by its truncated coneshaped structure, cannot inherently form such complexes due to its neutral surface. This article introduces anionic, cationic and zwitterionic (3-CD-based polyelectrolytes, detailing their synthesis routes and unique properties. Furthermore, it summarizes the diverse dosage forms, such as nanoparticles, nanocapsules, nanofibers, and hydrogels, that can be fabricated using (3-CD-based polyelectrolyte complexes. Additionally, the in vivo applications of these complexes in drug delivery systems, encompassing oral delivery, local drug delivery, and nucleic acid drug delivery, are systematically discussed.
引用
收藏
页数：21
相关论文
共 192 条
  • [51] Amphoteric, Prevailingly Cationic L-Arginine Polymers of Poly( amidoamino acid) Structure: Synthesis, Acid/Base Properties and Preliminary Cytocompatibility and Cell-Permeating Characterizations
    Ferruti, Paolo
    Mauro, Nicolo
    Falciola, Luigi
    Pifferi, Valentina
    Bartoli, Cristina
    Gazzarri, Matteo
    Chiellini, Federica
    Ranucci, Elisabetta
    [J]. MACROMOLECULAR BIOSCIENCE, 2014, 14 (03) : 390 - 400
  • [52] Poly(amidoamine)s: Past, present, and perspectives
    Ferruti, Paolo
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2013, 51 (11) : 2319 - 2353
  • [53] A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor
    Fitzgerald, Kathleen A.
    Malhotra, Meenakshi
    Gooding, Matt
    Sallas, Florence
    Evans, James C.
    Darcy, Raphael
    O'Driscoll, Caitriona M.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 499 (1-2) : 131 - 145
  • [54] Sulfobutylether-β-cyclodextrin/chitosan nano- and microparticles and their physicochemical characteristics
    Fulop, Zoltan
    Saokham, Phennapha
    Loftsson, Thorsteinn
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2014, 472 (1-2) : 282 - 287
  • [55] New multifunctional pharmaceutical excipient in tablet formulation based on citric acid-cyclodextrin polymer
    Garcia-Fernandez, Maria Jose
    Tabary, Nicolas
    Chai, Feng
    Cazaux, Frederic
    Blanchemain, Nicolas
    Flament, Marie-Pierre
    Martel, Bernard
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 511 (02) : 913 - 920
  • [56] Preparation and characterization of lamotrigine containing nanocapsules for nasal administration
    Gieszinger, Peter
    Csaba, Noemi Stefania
    Garcia-Fuentes, Marcos
    Prasanna, Maruthi
    Gaspar, Robert
    Sztojkov-Ivanov, Anita
    Ducza, Eszter
    Marki, Arpad
    Janaky, Tamas
    Kecskemeti, Gabor
    Katona, Gabor
    Szabo-Revesz, Piroska
    Ambrus, Rita
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2020, 153 : 177 - 186
  • [57] Self-assembling Modified β-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease
    Godinho, Bruno M. D. C.
    Ogier, Julien R.
    Darcy, Raphael
    Driscoll, Caitriona M.
    Cryan, John F.
    [J]. MOLECULAR PHARMACEUTICS, 2013, 10 (02) : 640 - 649
  • [58] Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?
    Gorzelanny, Christian
    Mess, Christian
    Schneider, Stefan W.
    Huck, Volker
    Brandner, Johanna M.
    [J]. PHARMACEUTICS, 2020, 12 (07) : 1 - 31
  • [59] Guo J., 2017, Vitro Mechanistic Stud. Vivo Patient Derived Ther. Efficacy Mol. Pharm., V14, P940
  • [60] Comparative study of β-cyclodextrin and carboxymethyl-β-cyclodextrin as effective drug delivery systems for oxymetholone: Design, preparation, characterization, phase solubility and in vitro drug release studies
    Hadadian, Mehrdad
    Allahyari, Reza
    Mahdavi, Behnam
    Mohammadhosseini, Majid
    [J]. JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES, 2024, 9 (03):
12345678910