(3-Cyclodextrin-based polyelectrolyte complexes for drug delivery

Polyelectrolyte complexes represent versatile formulations arising from electrostatic interactions between oppositely charged polymers. (3-Cyclodextrin ((3-CD), a cyclic oligosaccharide characterized by its truncated coneshaped structure, cannot inherently form such complexes due to its neutral surface. This article introduces anionic, cationic and zwitterionic (3-CD-based polyelectrolytes, detailing their synthesis routes and unique properties. Furthermore, it summarizes the diverse dosage forms, such as nanoparticles, nanocapsules, nanofibers, and hydrogels, that can be fabricated using (3-CD-based polyelectrolyte complexes. Additionally, the in vivo applications of these complexes in drug delivery systems, encompassing oral delivery, local drug delivery, and nucleic acid drug delivery, are systematically discussed.