(3-Cyclodextrin-based polyelectrolyte complexes for drug delivery

被引：0
作者：
Zhao, Rongrong [1 ]
Tang, Bo [1 ]
Xu, Zhuoya [1 ]
Fang, Guihua [1 ]
机构：
[1] Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2025年 / 534卷
基金：
中国国家自然科学基金;
关键词：
Polyelectrolyte complexes; Anionic (3-Cyclodextrin; Cationic (3-Cyclodextrin; Dosage forms; Drug delivery; ETHER-BETA-CYCLODEXTRIN; IN-VITRO; SIRNA DELIVERY; GENE DELIVERY; CHOROIDAL NEOVASCULARIZATION; CHITOSAN NANOPARTICLES; POLYETHYLENIMINE PEI; CONTROLLED-RELEASE; INCLUSION COMPLEX; POLYMER;
D O I：
10.1016/j.ccr.2025.216581
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Polyelectrolyte complexes represent versatile formulations arising from electrostatic interactions between oppositely charged polymers. (3-Cyclodextrin ((3-CD), a cyclic oligosaccharide characterized by its truncated coneshaped structure, cannot inherently form such complexes due to its neutral surface. This article introduces anionic, cationic and zwitterionic (3-CD-based polyelectrolytes, detailing their synthesis routes and unique properties. Furthermore, it summarizes the diverse dosage forms, such as nanoparticles, nanocapsules, nanofibers, and hydrogels, that can be fabricated using (3-CD-based polyelectrolyte complexes. Additionally, the in vivo applications of these complexes in drug delivery systems, encompassing oral delivery, local drug delivery, and nucleic acid drug delivery, are systematically discussed.
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页数：21
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