Tuning up gene transcription via direct crosstalk of DNA and RNA methylation

被引：0
|
作者：
Deng, Xiaoqian [1 ,2 ]
Fan, Guoping [2 ,3 ]
机构：
[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
[3] Scintillon Inst, 6868 Nancy Ridge Dr, San Diego, CA 92121 USA
来源：
MOLECULAR CELL | 2025年 / 85卷 / 04期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.molcel.2025.01.030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In a recent Cell study,(1) Quarto et al. uncovered a mechanism by which the METTL3-METTL14-DNMT1 axis fine-tunes gene expression during embryonic stem cell (ESC) differentiation. This work highlights the interplay between epigenetics and epitranscriptomics, shedding light on how methylation of DNA and RNA coordinately regulates a subset of differentiation genes.
引用
收藏
页码：674 / 676
页数：3
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