Pd-Catalyzed/Ligand-Controlled Regioselective Asymmetric Hydrosulfonylation of Alkylallenes or Arylallenes

被引：0

作者：

Wu, Jing ^{[1
,2
,3
]}

Wang, Boyi ^{[1
,2
,3
]}

Zou, Jinghan ^{[1
,2
,3
]}

Guo, Xinman ^{[1
,2
,3
]}

Chang, Weixing ^{[1
,2
,3
]}

Liu, Lingyan ^{[1
,2
,3
]}

Cao, Xiaohui ^{[4
]}

Li, Jing ^{[1
,2
,3
,5
]}

机构：

[1] Nankai Univ, Natl Engn Res Ctr Pesticide, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, Natl Engn Res Ctr Pesticide, Tianjin 300071, Peoples R China

[3] Nankai Univ, Coll Chem, Tianjin 300071, Peoples R China

[4] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China

[5] Collaborat Innovat Ctr Chem Sci Engn Tianjin, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ALLENES SYNTHESIS; TERMINAL ALLENES; C-C; ALLYLATION; REGIODIVERGENT; HYDROALKOXYLATION; ALKOXYALLENES; CONSTRUCTION; ACCESS;

D O I：

10.1021/acs.orglett.4c04259

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The metal-catalyzed hydrofunctionalization reaction of allenes is an efficient approach for the construction of new allyl compounds. This work described a palladium-catalyzed/ligand-controlled asymmetric hydrosulfonylation of simple alkylallenes and arylallenes in the presence of Pd2dba3. Using a Josiphos or Segphos ligand, the alkylallenes or arylallenes could render the corresponding branched chiral allylsulfones with high yields and high enantioselectivities up to 90% and 99% ee, respectively.

引用

页码：1350 / 1355

页数：6

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