Circulating Extracellular Vesicles: An Effective Biomarker for Cancer Progression

被引:1
|
作者
Chatterjee, Madhura [1 ]
Gupta, Saurabh [2 ]
Nag, Sayoni [3 ]
Rehman, Ishita [4 ]
Parashar, Deepak [5 ]
Maitra, Arindam [1 ]
Das, Kaushik [1 ]
机构
[1] Natl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, India
[2] GLA Univ, Dept Biotechnol, Mathura 281406, India
[3] Brainware Univ, Dept Biotechnol, Barasat 700125, India
[4] Neotia Univ, Dept Biotechnol, Parganas 743368, India
[5] Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2024年 / 29卷 / 11期
关键词
biomarkers; cancer biomarkers; circulating extracellular vesicles; clinical trials; extracellular vesicles; therapeutics; POTENTIAL DIAGNOSTIC BIOMARKERS; EXOSOME-MEDIATED TRANSFER; INTERCELLULAR COMMUNICATION; CELLS PROMOTES; MESSENGER-RNA; PROGNOSTIC BIOMARKER; SERUM EXOSOMES; MICROVESICLES; EXPRESSION; MECHANISM;
D O I
10.31083/j.fbl2911375
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Extracellular vesicles (EVs), the ubiquitous part of human biology, represent a small heterogenous, membrane-enclosed body that contains a diverse payload including genetic materials in the form of DNA, RNAs, small non-coding RNAs, etc. mostly mirroring their source of origin. Since, a vast majority of research has been conducted on how nucleic acids, proteins, lipids, and metabolites, associated with EVs can be effectively utilized to identify disease progression and therapeutic responses in cancer patients, EVs are increasingly being touted as valuable and reliable identifiers of cancer biomarkers in liquid biopsies. However, the lack of comprehensive clinical validation and effective standardization protocols severely limits its applications beyond the laboratories. The present review focuses on understanding the role of circulating EVs in different cancers and how they could potentially be treated as cancer biomarkers, typically due to the presence of bioactive molecules such as small non-coding RNAs, RNAs, DNA, proteins, etc., and their utilization for fine-tuning therapies. Here, we provide a brief general biology of EVs including their classification and subsequently discuss the source of circulatory EVs, the role of their associated payload as biomarkers, and how different cancers affect the level of circulatory EVs population.
引用
收藏
页数:22
相关论文
共 50 条
  • [41] Extracellular Vesicles and Epigenetic Modifications Are Hallmarks of Melanoma Progression
    Mannavola, Francesco
    D'Oronzo, Stella
    Cives, Mauro
    Stucci, Luigia Stefania
    Ranieri, Girolamo
    Silvestris, Franco
    Tucci, Marco
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (01)
  • [42] The Role of Extracellular Vesicles in Melanoma Progression
    Lattmann, Evelyn
    Levesque, Mitchell P.
    CANCERS, 2022, 14 (13)
  • [43] Platelets Extracellular Vesicles as Regulators of Cancer Progression-An Updated Perspective
    Zmigrodzka, Magdalena
    Witkowska-Pilaszewicz, Olga
    Winnicka, Anna
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (15) : 1 - 18
  • [44] Surgical Trauma in Mice Modifies the Content of Circulating Extracellular Vesicles
    Mkrtchian, Souren
    Ebberyd, Anette
    Veerman, Rosanne E.
    Mendez-Lago, Maria
    Gabrielsson, Susanne
    Eriksson, Lars I.
    Gomez-Galan, Marta
    FRONTIERS IN IMMUNOLOGY, 2022, 12
  • [45] Extracellular Vesicles in Brain Tumor Progression
    D'Asti, Esterina
    Chennakrishnaiah, Shilpa
    Lee, Tae Hoon
    Rak, Janusz
    CELLULAR AND MOLECULAR NEUROBIOLOGY, 2016, 36 (03) : 383 - 407
  • [46] Do Circulating Extracellular Vesicles Strictly Reflect Bronchoalveolar Lavage Extracellular Vesicles in COPD?
    Tine, Mariaenrica
    Neri, Tommaso
    Biondini, Davide
    Bernardinello, Nicol
    Casara, Alvise
    Conti, Maria
    Minniti, Marianna
    Cosio, Manuel G.
    Saetta, Marina
    Celi, Alessandro
    Nieri, Dario
    Bazzan, Erica
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)
  • [47] Biomarker Organization in Circulating Extracellular Vesicles: New Applications in Detecting Neurodegenerative Diseases
    Lim, Carine Z. J.
    Natalia, Auginia
    Sundah, Noah R.
    Shao, Huilin
    ADVANCED BIOSYSTEMS, 2020, 4 (12)
  • [48] Role of extracellular vesicles in glioma progression
    Quezada, Claudia
    Torres, Angelo
    Niechi, Ignacio
    Uribe, Daniel
    Contreras-Duarte, Susana
    Toledo, Fernando
    San Martin, Rody
    Gutierrez, Jaime
    Sobrevia, Luis
    MOLECULAR ASPECTS OF MEDICINE, 2018, 60 : 38 - 51
  • [49] Extracellular vesicles in cancer diagnostics and therapeutics
    Shehzad, Adeeb
    Ul Islam, Salman
    Shahzad, Raheem
    Khan, Salman
    Lee, Young Sup
    PHARMACOLOGY & THERAPEUTICS, 2021, 223
  • [50] Circulating extracellular vesicles as non-invasive biomarker of rejection in heart transplant
    Castellani, Chiara
    Burrello, Jacopo
    Fedrigo, Marny
    Burrello, Alessio
    Bolis, Sara
    Di Silvestre, Dario
    Tona, Francesco
    Bottio, Tomaso
    Biemmi, Vanessa
    Toscano, Giuseppe
    Gerosa, Gino
    Thiene, Gaetano
    Basso, Cristina
    Longnus, Sarah L.
    Vassalli, Giuseppe
    Angelini, Annalisa
    Barile, Lucio
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2020, 39 (10) : 1136 - 1148