Biocompatibility and therapeutic efficacy of crosslinked hydrogel filled 3D-printed nerve conduit for sacral nerve injury repair

被引：0

作者：

Lu, Jiajia ^{[1
,2
]}

Li, Yongchuan ^{[1
]}

Cai, Jiao ^{[3
]}

Jin, Xingwei ^{[4
]}

Chu, Guangxin ^{[5
]}

Jin, Hai ^{[5
]}

Zhu, Lei ^{[2
]}

Chen, Aimin ^{[1
]}

机构：

[1] Tongji Univ, Shanghai Peoples Hosp 4, Sch Med, Dept Orthoped Trauma, 1279 Sanmen Rd, Shanghai 200434, Peoples R China

[2] Shanghai Changzheng Hosp, Dept Orthoped Trauma, 415 Feng Yang Rd, Shanghai 200434, Peoples R China

[3] Shanghai Changzheng Hosp, Dept Med Adm, Shanghai 200434, Peoples R China

[4] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Urol, Shanghai 200025, Peoples R China

[5] Gen Hosp Northern Theater Command, Dept Neurosurg, 83 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China

来源：

BIOMATERIALS | 2025年 / 320卷

基金：

中国国家自然科学基金;

关键词：

Sacral nerve injury; Neural repair; PCL nerve conduit; Hydrogel; Neural stem cells; SPINAL-CORD-INJURY; DEGENERATION; TAIL;

D O I：

10.1016/j.biomaterials.2025.123230

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Neurological system injuries are debilitating conditions that significantly impact patients' quality of life. This study investigated using a polycaprolactone (PCL) nerve conduit loaded with anti-epidermal growth factor receptor (EGFR) hydrogel and neural stem cells (NSCs) for treating sacral nerve injury (SNI) in rats to explore its neural repair effects. The results demonstrate that the combined transplantation therapy using a 3D printed scaffold filled with crosslinked hydrogel and NSCs effectively improves SNI, with the PCL Nerve conduit showing potential promotion of neuronal differentiation. This research outcome provides a novel approach to the treatment of nerve injuries.

引用

页数：18

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