Resting state connectivity biomarkers of seizure freedom after epilepsy surgery

被引:1
|
作者
Martinez-Lizana, Eva [1 ]
Brandt, Armin [1 ]
Duempelmann, Matthias [1 ]
Schulze-Bonhage, Andreas [1 ]
机构
[1] Univ Freiburg, Epilepsy Ctr, Med Ctr, Breisacher Str 64, D-79106 Freiburg, Germany
关键词
Epilepsy; Resting state; Connectivity; Epilepsy surgery; HD-EEG; Source localization; Network measures; DIRECTED FUNCTIONAL CONNECTIVITY; NETWORK; DYNAMICS;
D O I
10.1016/j.nicl.2024.103673
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
Alterations in brain networks may cause the lowering of the seizure threshold and hypersynchronization that underlie the recurrence of unprovoked seizures in epilepsy. The aim of this work is to estimate functional network characteristics, which may help predicting outcome of epilepsy surgery. Twenty patients were studied (11 females, 9 males, mean age 33 years) with scalp-recorded HD-EEG in resting state (eyes closed, no interictal discharges) before intracranial evaluation, which allowed the precise determination of the epileptogenic zone. Dipole source time courses in the brain were estimated using Weighted Minimum Norm Estimate based on HD-EEG signals. Information inflow and outflow of atlas-based brain regions were computed using partial directed connectivity. A set of graph measures for pairwise connections in standard EEG frequency bands was calculated. After epilepsy surgery 10 patients were seizure-free (Engel 1a) and 10 patients continued suffering from seizures (Engel outcome worse than 1a). Inflow of the regions containing the epileptogenic zone in the beta and delta frequency bands was significantly lower in patients who achieved seizure-freedom after surgery, compared with patients who continued to have seizures (p = 0.012, and p = 0.026, respectively). Average path length in the beta frequency band was significantly higher in patients who achieved seizure freedom (p = 0.012). In the delta frequency band, local efficiency and clustering coefficient were significantly higher in patients who achieved seizure freedom (0.033, 0.046). In patients who achieved seizure freedom after surgery, the preoperative analysis of the epileptic network exhibited stronger separation of the region containing the seizure onset zone, with less inflow of information. In contrast, shorter paths within the epileptic network may facilitate hypersynchronous neuronal activity and thus the recurrence of seizures in non-seizure free patients. This study supports the hypothesis that epileptic network properties might help to define suitable candidates for epilepsy surgery.
引用
收藏
页数:6
相关论文
共 50 条
  • [41] Letter: Forecasting Seizure Freedom After Epilepsy Surgery Assessing Concordance Between Noninvasive and StereoEEG Findings
    Yue, Jiong
    Yang, Hui
    NEUROSURGERY, 2021, 88 (03) : E288 - E289
  • [43] In Reply: Forecasting Seizure Freedom After Epilepsy Surgery Assessing Concordance Between Noninvasive and StereoEEG Findings
    Uribe-San-Martin, Reinaldo
    Di Giacomo, Roberta
    Mai, Roberto
    Gozzo, Francesca
    Pelliccia, Veronica
    Mariani, Valeria
    Cardinale, Francesco
    Ciampi, Ethel
    Onofrj, Marco
    Tassi, Laura
    NEUROSURGERY, 2021, 88 (03) : E290 - E291
  • [44] Concordance between interictal MEG and stereo-EEG predicts seizure freedom after epilepsy surgery
    Bear, Joshua
    Kirsch, Heidi
    BRAIN, 2016, 139 : 2821 - 2823
  • [45] Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker
    Marino, Alexandria C.
    Yang, Genevieve J.
    Tyrtova, Evgeniya
    Wu, Kun
    Zaveri, Hitten P.
    Farooque, Pue
    Spencer, Dennis D.
    Bandt, S. Kathleen
    CLINICAL NEUROPHYSIOLOGY, 2019, 130 (02) : 280 - 288
  • [46] Daily resting-state intracranial EEG connectivity for seizure risk forecasts
    Cousyn, Louis
    Messaoud, Remy Ben
    Lehongre, Katia
    Frazzini, Valerio
    Lambrecq, Virginie
    Adam, Claude
    Mathon, Bertrand
    Navarro, Vincent
    Chavez, Mario
    EPILEPSIA, 2023, 64 (02) : E23 - E29
  • [47] When is a postoperative seizure equivalent to "epilepsy recurrence" after epilepsy surgery?
    Jehi, Lara
    Sarkis, Rani
    Bingaman, William
    Kotagal, Prakash
    Najm, Imad
    EPILEPSIA, 2010, 51 (06) : 994 - 1003
  • [48] Seizure outcome after epilepsy surgery in cryptogenic temporal lobe epilepsy
    Beydoun, A
    Minecan, D
    Selwa, L
    Passaro, E
    Edwards, J
    Ross, D
    Levy, K
    Nasreddine, W
    NEUROLOGY, 1999, 52 (06) : A163 - A163
  • [49] The duration of temporal lobe epilepsy and seizure outcome after epilepsy surgery
    Lowe, Natalie Marie
    Eldridge, Paul
    Varma, Thelekat
    Wieshmann, Udo C.
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2010, 19 (05): : 261 - 263
  • [50] Interictal SEEG Resting-State Connectivity Localizes the Seizure Onset Zone and Predicts Seizure Outcome
    Jiang, Haiteng
    Kokkinos, Vasileios
    Ye, Shuai
    Urban, Alexandra
    Bagic, Anto
    Richardson, Mark
    He, Bin
    ADVANCED SCIENCE, 2022, 9 (18)