Cardiac Magnetic Resonance Evaluation of LV Remodeling Post-Myocardial Infarction Prognosis, Monitoring and Trial Endpoints

被引:1
作者
Gissler, Mark Colin [1 ,2 ]
Antiochos, Panagiotis [3 ]
Ge, Yin [4 ,5 ]
Heydari, Bobak
Grani, Christoph [6 ]
Kwong, Raymond Y. [1 ,2 ]
机构
[1] Brigham & Womens Hosp, Dept Med, Cardiovasc Div, Noninvas Cardiovasc Imaging Sect, Boston, MA USA
[2] Brigham & Womens Hosp, Dept Radiol, Boston, MA USA
[3] Univ Freiburg, Univ Heart Ctr Freiburg Bad Krozingen, Fac Med, Dept Cardiol & Angiol, Freiburg, Germany
[4] Univ Hosp Lausanne, Cardiol & Cardiac MR Ctr, Lausanne, Switzerland
[5] Univ Toronto, St Michaels Hosp, Div Cardiol, Unity Hlth Toronto, Toronto, ON, Canada
[6] Univ Bern, Bern Univ Hosp, Dept Cardiol, Inselspital, Bern, Switzerland
关键词
cardiac magnetic resonance; fibrosis; heart failure; inflammation; LV remodeling; myocardial infarction; ACUTE MYOCARDIAL-INFARCTION; ST-SEGMENT-ELEVATION; PERCUTANEOUS CORONARY INTERVENTION; MICROVASCULAR OBSTRUCTION; HEART-FAILURE; INTRAMYOCARDIAL HEMORRHAGE; DELAYED ENHANCEMENT; INFLAMMATION; SIZE; MRI;
D O I
10.1016/j.jcmg.2024.03.012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adverse left ventricular remodeling (ALVR) and subsequent heart failure after myocardial infarction (MI) remain a major cause of patient morbidity and mortality worldwide. Overt inflammation has been identified as the common pathway underlying myocardial fibrosis and development of ALVR post-MI. With its ability to simultaneously provide information about cardiac structure, function, perfusion, and tissue characteristics, cardiac magnetic resonance (CMR) is well poised to inform prognosis and guide early surveillance and therapeutics in high-risk cohorts. Further, established and evolving CMR-derived biomarkers may serve as clinical endpoints in prospective trials evaluating the efficacy of novel anti-inflammatory and antifibrotic therapies. This review provides an overview of post-MI ALVR and illustrates how CMR may help clinical adoption of novel therapies via mechanistic or prognostic imaging markers.
引用
收藏
页码:1366 / 1380
页数:15
相关论文
共 109 条
  • [11] Redefining Adverse and Reverse Left Ventricular Remodeling by Cardiovascular Magnetic Resonance Following ST-Segment-Elevation Myocardial Infarction and Their Implications on Long-Term Prognosis
    Bulluck, Heerajnarain
    Carberry, Jaclyn
    Carrick, David
    McEntegart, Margaret
    Petrie, Mark C.
    Eteiba, Hany
    Hood, Stuart
    Watkins, Stuart
    Lindsay, Mitchell
    Mahrous, Ahmed
    Ford, Ian
    Oldroyd, Keith G.
    Berry, Colin
    [J]. CIRCULATION-CARDIOVASCULAR IMAGING, 2020, 13 (07)
  • [12] Cardiovascular Magnetic Resonance in Acute ST-Segment-Elevation Myocardial Infarction Recent Advances, Controversies, and Future Directions
    Bulluck, Heerajnarain
    Dharmakumar, Rohan
    Arai, Andrew E.
    Berry, Colin
    Hausenloy, Derek J.
    [J]. CIRCULATION, 2018, 137 (18) : 1949 - 1964
  • [13] Defining left ventricular remodeling following acute ST-segment elevation myocardial infarction using cardiovascular magnetic resonance
    Bulluck, Heerajnarain
    Go, Yun Yun
    Crimi, Gabriele
    Ludman, Andrew J.
    Rosmini, Stefania
    Abdel-Gadir, Amna
    Bhuva, Anish N.
    Treibel, Thomas A.
    Fontana, Marianna
    Pica, Silvia
    Raineri, Claudia
    Sirker, Alex
    Herrey, Anna S.
    Manisty, Charlotte
    Groves, Ashley
    Moon, James C.
    Hausenloy, Derek J.
    [J]. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2017, 19
  • [14] Myocardial Infarct Size by CMR in Clinical Cardioprotection Studies Insights From Randomized Controlled Trials
    Bulluck, Heerajnarain
    Hammond-Haley, Matthew
    Weinmann, Shane
    Martinez-Macias, Roberto
    Hausenloy, Derek J.
    [J]. JACC-CARDIOVASCULAR IMAGING, 2017, 10 (03) : 230 - 240
  • [15] Automated Extracellular Volume Fraction Mapping Provides Insights Into the Pathophysiology of Left Ventricular Remodeling Post-Reperfused ST-Elevation Myocardial Infarction
    Bulluck, Heerajnarain
    Rosmini, Stefania
    Abdel-Gadir, Amna
    White, Steven K.
    Bhuva, Anish N.
    Treibel, Thomas A.
    Fontana, Marianna
    Gonzalez-Lopez, Esther
    Reant, Patricia
    Ramlall, Manish
    Hamarneh, Ashraf
    Sirker, Alex
    Herrey, Anna S.
    Manisty, Charlotte
    Yellon, Derek M.
    Kellman, Peter
    Moon, James C.
    Hausenloy, Derek J.
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (07):
  • [16] Residual Myocardial Iron Following Intramyocardial Hemorrhage During the Convalescent Phase of Reperfused ST-Segment-Elevation Myocardial Infarction and Adverse Left Ventricular Remodeling
    Bulluck, Heerajnarain
    Rosmini, Stefania
    Abdel-Gadir, Amna
    White, Steven K.
    Bhuva, Anish N.
    Treibel, Thomas A.
    Fontana, Marianna
    Ramlall, Manish
    Hamarneh, Ashraf
    Sirker, Alex
    Herrey, Anna S.
    Manisty, Charlotte
    Yellon, Derek M.
    Kellman, Peter
    Moon, James C.
    Hausenloy, Derek J.
    [J]. CIRCULATION-CARDIOVASCULAR IMAGING, 2016, 9 (10)
  • [17] Persistent Iron Within the Infarct Core After ST-Segment Elevation Myocardial Infarction Implications for Left Ventricular Remodeling and Health Outcomes
    Carberry, Jaclyn
    Carrick, David
    Haig, Caroline
    Ahmed, Nadeem
    Mordi, Ify
    McEntegart, Margaret
    Petrie, Mark C.
    Eteiba, Hany
    Hood, Stuart
    Watkins, Stuart
    Lindsay, Mitchell
    Davie, Andrew
    Mahrous, Ahmed
    Ford, Ian
    Sattar, Naveed
    Welsh, Paul
    Radjenovic, Aleksandra
    Oldroyd, Keith G.
    Berry, Colin
    [J]. JACC-CARDIOVASCULAR IMAGING, 2018, 11 (09) : 1248 - 1256
  • [18] Remote Zone Extracellular Volume and Left Ventricular Remodeling in Survivors of ST-Elevation Myocardial Infarction
    Carberry, Jaclyn
    Carrick, David
    Haig, Caroline
    Rauhalammi, Samuli M.
    Ahmed, Nadeem
    Mordi, Ify
    McEntegart, Margaret
    Petrie, Mark C.
    Eteiba, Hany
    Hood, Stuart
    Watkins, Stuart
    Lindsay, Mitchell
    Davie, Andrew
    Mahrous, Ahmed
    Ford, Ian
    Sattar, Naveed
    Welsh, Paul
    Radjenovic, Aleksandra
    Oldroyd, Keith G.
    Berry, Colin
    [J]. HYPERTENSION, 2016, 68 (02) : 385 - +
  • [19] Temporal Evolution of Myocardial Hemorrhage and Edema in Patients After Acute ST-Segment Elevation Myocardial Infarction: Pathophysiological Insights and Clinical Implications
    Carrick, David
    Haig, Caroline
    Ahmed, Nadeem
    Rauhalammi, Samuli
    Clerfond, Guillaume
    Carberry, Jaclyn
    Mordi, Ify
    McEntegart, Margaret
    Petrie, Mark C.
    Eteiba, Hany
    Hood, Stuart
    Watkins, Stuart
    Lindsay, M. Mitchell
    Mahrous, Ahmed
    Welsh, Paul
    Sattar, Naveed
    Ford, Ian
    Oldroyd, Keith G.
    Radjenovic, Aleksandra
    Berry, Colin
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (02):
  • [20] Left Ventricular Remodelling: A Problem in Search of Solutions
    Cokkinos, Dennis V.
    Belogianneas, Christos
    [J]. EUROPEAN CARDIOLOGY REVIEW, 2016, 11 (01) : 29 - 35