What immunology has to say about pesticide safety

被引:0
作者
Friedrich, Adrian David [1 ]
Zwirner, Norberto Walter [1 ,2 ]
机构
[1] Lab Fisiopatol Inmun Innata IBYME CONICET, Buenos Aires, Argentina
[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Buenos Aires, Argentina
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
pesticides - adverse effects; immunotoxicity evaluation; cancer; anti-tumor immunity; immunosurveilance; GLYPHOSATE-BASED HERBICIDES; CANCER; INDUCTION; EXPOSURE; ATRAZINE; CELLS;
D O I
10.3389/fimmu.2024.1487805
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The use of pesticides has enabled the development of contemporary industrial agriculture and significantly increased crop yields. However, they are also considered a source of environmental pollution and a potential hazard to human health. Despite national agencies and the scientific community analyzing pesticide safety, immunotoxicity assays are often not required, poorly designed, or underestimated. Epidemiological evidence indicates that pesticide exposure increases the risk of developing cancer. Therefore, pesticides may not only act as carcinogens per se but also as immunosuppressive agents that create a permissive context for tumor development. Given recent evidence demonstrating the critical role of the immune response in cancer progression, we will highlight the necessity of assessing the potential impacts of pesticides on the immune response, particularly on tumor immunosurveillance. In this Perspective article, we will focus on the need to critically review fundamental aspects of toxicological studies conducted on pesticides to provide a clearer understanding of the risks associated with exposure to these compounds to human health.
引用
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页数:6
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