Spatial metabolomics in mental disorders and traditional Chinese medicine: a review

被引：0

作者：

Lei, Chaofang ^{[1
]}

Chen, Jiaxu ^{[2
]}

Chen, Zhigang ^{[3
]}

Ma, Chongyang ^{[4
]}

Chen, Xudong ^{[5
]}

Sun, Xiongxing ^{[1
]}

Tang, Xukun ^{[1
]}

Deng, Jun ^{[1
]}

Wang, Shiliang ^{[1
]}

Jiang, Junlin ^{[1
]}

Wu, Dahua ^{[1
]}

Xie, Le ^{[1
]}

机构：

[1] Hunan Acad Tradit Chinese Med, Hunan Prov Hosp Integrated Tradit Chinese & Wester, Affiliated Hosp, Dept Neurol, Changsha, Peoples R China

[2] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China

[3] Beijing Univ Chinese Med, Dongfang Hosp, Dept Neurol, Beijing, Peoples R China

[4] Capital Med Univ, Sch Tradit Chinese Med, Beijing, Peoples R China

[5] Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2025年 / 16卷

基金：

中国国家自然科学基金;

关键词：

mental disorders; traditional Chinese medicine; spatial metabolomics; mass spectrometry imaging; DESI-MSI; MALDI-MSI; SIMS; IONIZATION MASS-SPECTROMETRY; 5-ELEMENT MUSIC-THERAPY; LIQUID-CHROMATOGRAPHY; VISUALIZATION ANALYSIS; QUANTITATIVE-ANALYSIS; PANAX-GINSENG; MATRIX; LOCALIZATION; DEPRESSION; METABOLITES;

D O I：

10.3389/fphar.2025.1449639

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spatial metabolomics is an emerging technology that integrates mass spectrometry imaging (MSI) with metabolomics, offering a novel visual perspective for traditional metabolomics analysis. This technology enables in-depth analysis in three dimensions: qualitative, quantitative, and localization of metabolites. Spatial metabolomics precisely reflects the characteristics of metabolic network changes in metabolites within entire tissues or specific micro-regions. It provides a detailed understanding of the pharmacodynamic material basis and mechanisms of action. These capabilities suggest that spatial metabolomics can offer significant technical support for studying the complex pathophysiology of mental disorders. Although the mechanisms underlying mental disorders have been reviewed multiple times, this paper provides a comprehensive comparison between traditional metabolomics and spatial metabolomics. It also summarizes the latest progress and challenges of applying spatial metabolomics to the study of mental disorders and traditional Chinese medicine.

引用

页数：19

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