An Acetic Acid-Promoted Strecker Type Reaction of N,N-Disubstituted Aminomalononitriles: An Efficient Way for the Construction of α-Aminonitriles

被引：0

作者：

Wang, Bo-Wen ^{[1
,2
,3
]}

Pu, Yan-Lin ^{[1
,2
,3
]}

Li, Run-Ze ^{[1
,2
,3
]}

Li, Bai-Yang ^{[1
,2
,3
]}

Jiao, Hai-Juan ^{[1
,2
,3
]}

Bai, Yin-Liang ^{[1
,2
,3
]}

Bao, Wen ^{[1
,2
,3
]}

Zhang, Ye ^{[1
,2
,3
]}

Zhu, Dao-Yong ^{[1
,2
,3
]}

Wang, Shao-Hua ^{[1
,2
,3
]}

机构：

[1] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Lanzhou Univ, Collaborat Innovat Ctr Northwestern Chinese Med, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 13期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

AMINO NITRILES; CYANATION; CYANIDE;

D O I：

10.1021/acs.joc.4c02945

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Strecker type reaction between aldehydes and readily available N,N-disubstituted aminomalononitriles has been realized for the first time to give an alternative strategy for the synthesis of alpha-aminonitriles. This reaction features broad substrate scope and the use of water as solvent, and its utility has been supported by the formal synthesis of racemic Clopidogrel and a 3-aminoindole type of compound.

引用

页码：4748 / 4758

页数：11

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