A posterior insula to lateral amygdala pathway transmits US-offset information with a limited role in fear learning

被引：0

作者：

Palchaudhuri, Shriya ^{[1
,2
]}

Lin, Bei-Xuan ^{[1
]}

Osypenko, Denys ^{[1
,3
]}

Wu, Jinyun ^{[1
]}

Kochubey, Olexiy ^{[1
]}

Schneggenburger, Ralf ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne EPFL, Brain Mind Inst, Sch Life Sci, Lab Synapt Mech, Lausanne, Switzerland

[2] NYU, Grossman Sch Med, Neurosci Inst, New York, NY USA

[3] Univ Lausanne, Dept Fundamental Neurosci, Lausanne, Switzerland

来源：

CELL REPORTS | 2025年 / 44卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

LONG-TERM POTENTIATION; BASOLATERAL AMYGDALA; GABAERGIC NEURONS; CORTEX; RAT; RESPONSES; MEMORY; PROJECTIONS; MECHANISMS; CIRCUITS;

D O I：

10.1016/j.celrep.2025.115320

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During fear learning, associations between a sensory cue (conditioned stimulus, CS) and an aversive stimulus (unconditioned stimulus, US) are formed in specific brain circuits. The lateral amygdala (LA) is involved in CS- US integration; however, US pathways to the LA remain understudied. Here, we investigated whether the posterior insular cortex (pInsCx), a hub for aversive state signaling, transmits US information to the LA during fear learning. We find that the pInsCx makes a robust, glutamatergic projection specifically targeting the anterior LA. In vivo Ca2+ imaging reveals that neurons in the pInsCx and anterior LA display US-onset and US-offset responses; imaging combined with axon silencing shows that the pInsCx selectively transmits US-offset information to the anterior LA. Optogenetic silencing, however, does not show a role for US-driven activity in the anterior LA or its pInsCx afferents in fear memory formation. Thus, we describe a cortical projection that carries US-offset information to the amygdala with a limited role in fear learning.

引用

页数：26